About: Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus
Creator	Belouzard, Sandrine Dubuisson, Jean Séron, Karin Barras, Alexandre Boukherroub, Rabah Chen, Yen-Ting Giovanelli, Emerson Metzler-Nolte, Nils Szunerits, Sabine
source	Medline; PMC
abstract	[Image: see text] Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are biologically diverse and rapidly mutating. In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated. The first generation of antiviral CQDs was derived from hydrothermal carbonization of ethylenediamine/citric acid as carbon precursors and postmodified with boronic acid ligands. These nanostructures showed a concentration-dependent virus inactivation with an estimated EC(50) of 52 ± 8 μg mL(–1). CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC(50) lowered to 5.2 ± 0.7 μg mL(–1). The underlying mechanism of action of these CQDs was revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step.
has issue date	2019-10-21(xsd:dateTime)
bibo:doi	10.1021/acsami.9b15032
bibo:pmid	31633330
has license	bronze-oa
sha1sum (hex)	af674b65ddf992e5f77b5198b6be6e8c728c21c3
schema:url	https://doi.org/10.1021/acsami.9b15032
resource representing a document's title	Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus
has PubMed Central identifier	PMC7075527
has PubMed identifier	31633330
schema:publication	ACS Applied Materials & Interfaces
resource representing a document's body	covid:af674b65ddf992e5f77b5198b6be6e8c728c21c3#body_text
is schema:about of	named entity 'MEDICAL COUNTERMEASURES' named entity 'QUANTUM DOTS' named entity 'CARBON' named entity 'FUNCTIONAL' named entity 'HUMAN CORONAVIRUS' named entity 'SUPPORTING INFORMATION' named entity 'Medical' named entity 'photoelectrons' named entity 'fluorescence' named entity 'CH2Cl2' named entity 'Teflon' named entity 'room temperature' named entity 'turbid' named entity 'chromatography' named entity 'digestion' named entity 'kDa' named entity 'France' named entity 'Teflon' named entity 'monochromator' named entity 'digestion' named entity 'autoclave' named entity 'spectra' named entity 'autoclave' named entity '2.1' named entity 'degassed' named entity 'dark orange' named entity 'citric acid' named entity 'microbalance' named entity 'nitrogen gas' named entity 'dispersible' named entity 'X-rays' named entity 'room temperature' named entity 'autoclave' named entity 'lyophilized' named entity 'spectrometer' named entity 'dialyzed' named entity 'FTIR' named entity 'aniline' named entity 'cellulose ester' named entity 'Teflon' named entity 'dissolved oxygen' named entity 'eluent' named entity 'XPS' named entity 'aniline' named entity 'kDa' named entity 'ThermoScientific' named entity 'Infrared' named entity 'laser diode' named entity 'dialyzed' named entity 'Fluorescence spectroscopy' named entity 'ethanol' named entity 'FTIR' named entity 'autoclave' named entity 'dialysis' named entity 'France' named entity 'France' named entity 'spectral resolution' named entity 'X-ray' named entity 'Fourier Transform' named entity 'France' named entity 'Horiba' named entity 'vacuum' named entity 'Vacuum' named entity 'Teflon' named entity 'Biotech' named entity 'Milli-Q water' named entity 'pore size' named entity 'Visible light' named entity 'dialysis' named entity 'Teflon' named entity 'digestion' named entity 'X-ray Photoelectron Spectroscopy' named entity 'digestion'

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