About: Effect of cyclosporin A on an experimental chronic viral infection of the central nervous system

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About: Effect of cyclosporin A on an experimental chronic viral infection of the central nervous system Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of cyclosporin A on an experimental chronic viral infection of the central nervous system
Creator	Godfraind, C Boespflug, O Tardieu, M
topic	covid:af4a679a2b559e8fdbf77bb6502e7d22d72dd39f#this
Source	Elsevier; Medline; PMC
abstract	Abstract The effects of cyclosporin A (CsA) on neuropathological lesions induced by a chronic viral infection have been tested in the experimental model of the mouse hepatitis virus 3 (MHV3) infection. Daily injections of CsA (50 mg/kg) inhibited the expression of the MHV3-induced ependymitis, meningitis, hydrocephalus and vasculitis. The effect was preserved even if CsA treatment was initiated 15 days after virus infection but was lost if CsA treatment was given later on or for a shorter period of time. Viral titers in brains of chronically infected mice were not affected by CsA treatment. During the first week following MHV3 infection, CsA treatment increased both the percentage of acute death (31 vs. 10%) and the viral titers in brain and liver of infected mice. In this model, the timing of CsA treatment appeared critical for the balance between its beneficial effect on CNS lesions and the risk of increased acute mortality.
has issue date	1989-01-31(xsd:dateTime)
bibo:doi	10.1016/0165-5728(89)90158-6
bibo:pmid	2535702
has license	els-covid
sha1sum (hex)	af4a679a2b559e8fdbf77bb6502e7d22d72dd39f
schema:url	https://doi.org/10.1016/0165-5728%2889%2990158-6
resource representing a document's title	Effect of cyclosporin A on an experimental chronic viral infection of the central nervous system
has PubMed Central identifier	PMC7119832
has PubMed identifier	2535702
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:af4a679a2b559e8fdbf77bb6502e7d22d72dd39f#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/af4a679a2b559e8fdbf77bb6502e7d22d72dd39f
is schema:about of	named entity 'CHRONIC' named entity 'preserved' named entity 'lesions' named entity 'brains' named entity 'cyclosporin A' named entity 'mortality' named entity 'infected' named entity 'mouse' named entity 'CYCLOSPORIN A' named entity 'BRAINS' named entity 'BENEFICIAL EFFECT' named entity 'MODEL OF' named entity 'CRITICAL' named entity 'MOUSE HEPATITIS VIRUS' named entity 'DEATH' named entity 'INFECTION' named entity 'CSA' named entity 'LOST' named entity 'MICE' named entity 'CNS LESIONS' named entity 'FOLLOWING' named entity 'WEEK' named entity 'INDUCED' named entity 'MG%' named entity 'EPENDYMITIS' named entity 'TIMING' named entity 'PERIOD OF TIME' named entity 'HYDROCEPHALUS' named entity 'ITS' named entity 'TREATMENT' named entity 'MORTALITY' named entity 'MODEL' named entity '10%' named entity 'MENINGITIS' named entity 'TESTED' named entity 'BALANCE' named entity 'CYCLOSPORIN A' named entity 'BUT' named entity 'INCREASED' named entity 'LATER' named entity 'EFFECTS' named entity 'AFFECTED' named entity 'EFFECT' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'DAILY' named entity 'EXPERIMENTAL MODEL' named entity 'RISK OF' named entity 'PRESERVED' named entity 'CHRONIC' named entity 'INJECTIONS' named entity 'ACUTE' named entity 'BRAIN' named entity 'INFECTED' named entity 'VIRAL' named entity 'VIRAL INFECTION' named entity 'LESIONS' named entity 'GIVEN' named entity 'LIVER' named entity 'EXPRESSION' named entity 'INHIBITED' named entity 'HAVE' named entity 'PERCENTAGE' named entity 'VASCULITIS' named entity 'VIRAL INFECTION' named entity 'EXPERIMENTAL' named entity 'EFFECT' named entity 'DAYS' covid:arg/af4a679a2b559e8fdbf77bb6502e7d22d72dd39f named entity 'injections' named entity 'CsA' named entity 'expression' named entity 'hydrocephalus' named entity 'induced' named entity 'initiated' named entity 'neuropathological' named entity 'week' named entity 'effects'

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