About: The Effectiveness and Mechanism of Toona sinensis Extract Inhibit Attachment of Pandemic Influenza A (H1N1) Virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Effectiveness and Mechanism of Toona sinensis Extract Inhibit Attachment of Pandemic Influenza A (H1N1) Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Effectiveness and Mechanism of Toona sinensis Extract Inhibit Attachment of Pandemic Influenza A (H1N1) Virus
Creator	Chen, Chung-Jen Huang, Sheng-Teng Liao, Pei-Lin You, Huey-Ling Eng, Hock-Liew
Source	Medline; PMC
abstract	TSL-1 is a fraction of the aqueous extract from the tender leaf of Toona sinensis Roem, a nutritious vegetable. The pandemic influenza A (H1N1) virus is a recently described, rapidly contagious respiratory pathogen which can cause acute respiratory distress syndrome (ARDS) and poses a major public health threat. In this study, we found that TSL-1 inhibited viral yields on MDCK plaque formation by pandemic influenza A (H1N1) virus on infected A549 cells with high selectivity index. Meanwhile, TSL-1 also suppressed viral genome loads in infected A549 cells, quantified by qRT-PCR. This study further demonstrated that TSL-1 inhibited pandemic influenza A (H1N1) virus activity through preventing attachment of A549 cells but not penetration. TSL-1 inhibited viral attachment through significant downregulation of adhesion molecules and chemokines (VCAM-1, ICAM-1, E-selectin, IL-8, and fractalkine) compared to Amantadine. Our results suggest that TSL-1 may be used as an alternative treatment and prophylaxis against pandemic influenza A (H1N1) virus.
has issue date	2013-09-02(xsd:dateTime)
bibo:doi	10.1155/2013/479718
bibo:pmid	24073006
has license	cc-by
sha1sum (hex)	aef63beff452ee2eee54c7d60770dccf59890568
schema:url	https://doi.org/10.1155/2013/479718
resource representing a document's title	The Effectiveness and Mechanism of Toona sinensis Extract Inhibit Attachment of Pandemic Influenza A (H1N1) Virus
has PubMed Central identifier	PMC3773900
has PubMed identifier	24073006
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:aef63beff452ee2eee54c7d60770dccf59890568#body_text
is schema:about of	named entity 'respiratory' named entity 'TSL' named entity 'E-selectin' named entity 'A549' named entity 'poses' named entity 'Effectiveness' covid:arg/aef63beff452ee2eee54c7d60770dccf59890568 named entity 'contagious' named entity 'quantified' named entity 'virus' named entity 'TSL' named entity 'selectivity' named entity 'attachment' named entity 'inhibited' named entity 'TSL' named entity 'study' named entity 'Virus' named entity 'H1N1' named entity 'Toona sinensis' named entity 'VCAM-1' named entity 'plaque formation' named entity 'downregulation' named entity 'MDCK' named entity 'prophylaxis' named entity 'pandemic influenza' named entity 'virus' named entity 'pandemic influenza' named entity 'vegetable' named entity 'TSL' named entity 'alternative treatment' named entity 'virus' named entity 'pandemic influenza' named entity 'chemokines' named entity 'adhesion molecules' named entity 'qRT-PCR' named entity 'Virus' named entity 'TSL' named entity 'dose-response curves' named entity 'upper respiratory infection' named entity 'multiple comparisons' named entity 'IL-8' named entity 'quercetin' named entity 'isothiocyanate' named entity 'Amantadine' named entity 'viral adsorption' named entity 'ovarian cancer' named entity 'spectrophotometrically' named entity 'H1N1' named entity 'IL-1' named entity 'plaque assay' named entity 'H1N1' named entity 'Amantadine' named entity 'Bcl2' named entity 'H1N1' named entity 'fractalkine' named entity 'chemokines' named entity 'A549' named entity 'host cell' named entity 'respiratory syncytial virus' named entity 'gene' named entity 'PBS' named entity 'supernatants' named entity 'TTT' named entity 'A549' named entity 'high evolutionary' named entity 'chemokines' named entity 'MDCK' named entity 'Taiwan' named entity 'SARS' named entity 'host cell' named entity 'influenza virus' named entity 'influenza' named entity 'antiviral' named entity 'Toona sinensis' named entity 'Bcl2' named entity 'TLR3' named entity 'mice'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software