About: Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats

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About: Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
Creator	Wang, Yi Wang, Changjun Zhu, Jin Hu, Dan He, Ting Ai, Lele Ding, Chenxi Tan, Weilong Yang, Lu Ye, Fuqiang Zhu, Changqiang Feng, Youjun Hassan, Bachar Lv, Ruicheng Zhu, Xuhui
Source	Medline; PMC; WHO
abstract	SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. To further understand the evolutionary relationship between SARS-CoV and its reservoirs, 334 bats were collected from Zhoushan city, Zhejiang province, China, between 2015 and 2017. PCR amplification of the conserved coronaviral protein RdRp detected coronaviruses in 26.65% of bats belonging to this region, and this number was influenced by seasonal changes. Full genomic analyses of the two new SL-CoVs from Zhoushan (ZXC21 and ZC45) showed that their genomes were 29,732 nucleotides (nt) and 29,802 nt in length, respectively, with 13 open reading frames (ORFs). These results revealed 81% shared nucleotide identity with human/civet SARS CoVs, which was more distant than that observed previously for bat SL-CoVs in China. Importantly, using pathogenic tests, we found that the virus can reproduce and cause disease in suckling rats, and further studies showed that the virus-like particles can be observed in the brains of suckling rats by electron microscopy. Thus, this study increased our understanding of the genetic diversity of the SL-CoVs carried by bats and also provided a new perspective to study the possibility of cross-species transmission of SL-CoVs using suckling rats as an animal model.
has issue date	2018-09-12(xsd:dateTime)
bibo:doi	10.1038/s41426-018-0155-5
bibo:pmid	30209269
has license	cc-by
sha1sum (hex)	aeaf5bd4725051f6926d06450566673d1cc4a639
schema:url	https://doi.org/10.1038/s41426-018-0155-5
resource representing a document's title	Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
has PubMed Central identifier	PMC6135831
has PubMed identifier	30209269
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:aeaf5bd4725051f6926d06450566673d1cc4a639#body_text
is schema:about of	named entity 'COVS' named entity 'SARS CORONAVIRUS' named entity 'PATHOGENIC' named entity 'TRANSMISSION' named entity 'BATS' named entity '2015' named entity 'BAT' named entity 'UNDERSTANDING' named entity 'SPECIES' named entity 'COLLECTED' named entity 'RDRP' named entity 'REPRODUCE' named entity 'ANIMAL MODEL' named entity 'AFRICA' named entity 'THEIR' named entity 'LARGE' named entity 'CHINA' named entity 'DISTANT' named entity 'GENETIC DIVERSITY' named entity 'SARS-LIKE CORONAVIRUS' named entity 'study' named entity 'studies' named entity 'tests' named entity 'Zhejiang' named entity 'SARS-like coronavirus' covid:arg/aeaf5bd4725051f6926d06450566673d1cc4a639 named entity 'OUTBREAK' named entity 'UNDERSTAND' named entity 'NUCLEOTIDE' named entity 'SARS' named entity 'VIRUS-LIKE PARTICLES' named entity '334' named entity 'FOUND' named entity 'BRAINS' named entity 'ZHEJIANG PROVINCE' named entity 'LENGTH' named entity 'HAVE' named entity 'RATS' named entity 'BELONGING' named entity 'CORONAVIRUSES' named entity 'RELATIONSHIP' named entity 'CROSS' named entity 'REGION' named entity 'RESULTS' named entity 'DETECTED' named entity 'USING' named entity 'TESTS' named entity 'STUDY' named entity 'GENOMIC' named entity 'BATS' named entity 'INFECTIVITY' named entity 'NOVEL' named entity 'CHARACTERIZATION' named entity 'CHINESE' named entity 'SEASONAL' named entity 'RESERVOIRS' named entity 'CONSERVED' named entity 'THESE' named entity 'RESIDE' named entity 'REVEALED' named entity 'ELECTRON MICROSCOPY' named entity 'CAUSATIVE AGENT' named entity 'NUMBER' named entity 'PREVIOUSLY' named entity 'ITS' named entity 'INCREASED' named entity 'SHARED'

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