About: One time intranasal vaccination with a modified vaccinia Tiantan strain MVTTZCI protects animals against pathogenic viral challenge

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About: One time intranasal vaccination with a modified vaccinia Tiantan strain MVTTZCI protects animals against pathogenic viral challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	One time intranasal vaccination with a modified vaccinia Tiantan strain MVTTZCI protects animals against pathogenic viral challenge
Creator	Chen, Zhiwei Zhang, Linqi Tien, Po Fang, Qing Wang, Haibo Yu, Wenbo Zhu, Weijun
topic	covid:ae7eb643b9434689092354a21abd88ea9c65926a#this
Source	Elsevier; Medline; PMC
abstract	Abstract To combat variola virus in bioterrorist attacks, it is desirable to develop a noninvasive vaccine. Based on the vaccinia Tiantan (VTT) strain, which was historically used to eradicate the smallpox in China, we generated a modified VTT (MVTTZCI) by removing the hemagglutinin gene and an 11,944bp genomic region from HindIII fragment C2L to F3L. MVTTZCI was characterized for its host cell range in vitro and preclinical safety and efficacy profiles in mice. Despite replication-competency in some cell lines, unlike VTT, MVTTZCI did not cause death after intracranial injection or body weight loss after intranasal inoculation. MVTTZCI did not replicate in mouse brain and was safe in immunodeficient mice. MVTTZCI induced neutralizing antibodies via the intranasal route of immunization. One time intranasal immunization protected animals from the challenge of the pathogenic vaccinia WR strain. This study established proof-of-concept that the attenuated replicating MVTTZCI may serve as a safe noninvasive smallpox vaccine candidate.
has issue date	2010-02-25(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2009.12.038
bibo:pmid	20045097
has license	els-covid
sha1sum (hex)	ae7eb643b9434689092354a21abd88ea9c65926a
schema:url	https://doi.org/10.1016/j.vaccine.2009.12.038
resource representing a document's title	One time intranasal vaccination with a modified vaccinia Tiantan strain MVTTZCI protects animals against pathogenic viral challenge
has PubMed Central identifier	PMC7127290
has PubMed identifier	20045097
schema:publication	Vaccine
resource representing a document's body	covid:ae7eb643b9434689092354a21abd88ea9c65926a#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ae7eb643b9434689092354a21abd88ea9c65926a
is schema:about of	named entity 'ANIMALS' named entity 'eradicate' named entity 'HindIII' named entity 'safety' named entity 'bioterrorist' named entity 'desirable' named entity 'range' named entity 'VACCINE' named entity 'STUDY' named entity 'NONINVASIVE' named entity 'ATTENUATED' named entity 'SMALLPOX' named entity 'STRAIN' named entity 'MICE' named entity 'VACCINE CANDIDATE' named entity 'BASED' named entity 'IMMUNODEFICIENT' named entity 'HEMAGGLUTININ' named entity 'SAFE' named entity 'IMMUNIZATION' named entity 'CHARACTERIZED' covid:arg/ae7eb643b9434689092354a21abd88ea9c65926a named entity 'ITS' named entity 'RANGE' named entity 'CHALLENGE' named entity 'BODY WEIGHT LOSS' named entity 'COMBAT' named entity 'REGION' named entity 'SERVE' named entity 'PATHOGENIC' named entity 'VACCINIA' named entity 'ONE TIME' named entity 'ZCI' named entity 'MODIFIED' named entity 'VIRAL' named entity 'STRAIN' named entity 'VARIOLA VIRUS' named entity 'ESTABLISHED' named entity 'INJECTION' named entity 'INTRACRANIAL' named entity 'HOST CELL' named entity 'CHALLENGE' named entity 'GENOMIC' named entity 'FRAGMENT' named entity 'SAFETY' named entity 'REPLICATE' named entity 'DID' named entity 'EFFICACY' named entity 'MODIFIED' named entity 'ONE TIME' named entity 'REPLICATION' named entity 'SMALLPOX VACCINE' named entity 'CHINA' named entity 'CONCEPT' named entity 'INTRANASAL VACCINATION' named entity 'ZCI' named entity 'PATHOGENIC' named entity 'INTRANASAL INOCULATION' named entity 'ATTACKS' named entity 'OF-' named entity 'MOUSE BRAIN' named entity 'INTRANASAL IMMUNIZATION' named entity 'IN VITRO' named entity 'REMOVING' named entity 'NEUTRALIZING ANTIBODIES' named entity 'INTRANASAL ROUTE' named entity 'PRECLINICAL' named entity 'CAUSE DEATH' named entity 'INDUCED' named entity 'USED' named entity 'CELL LINES' named entity 'VACCINIA' named entity 'GENERATED'

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