About: Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues

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About: Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues
Creator	Thomas, Elizabeth Thomas, Ba, Elizabeth Ba, Megan Genetics, Juno House, Winchester Leaver, Leaver, Megan Stanley, Kate Wells, Dagan
source	Elsevier; Medline; PMC
abstract	Abstract Objective To identify cell types in the male and female reproductive systems at risk of SARS-CoV-2 infection due to expression of host genes and proteins used by the virus for cell entry. Design Descriptive analysis of transcriptomic and proteomic data. Setting Academic research department and clinical diagnostic laboratory. Patients/Animals None. Focused on previously generated gene and protein expression data. Intervention(s) None. Main Outcome Measure(s) Identification of cell types co-expressing the key ACE2 and TMPRSS2 genes and proteins, as well as other candidates potentially involved in SARS-CoV-2 cell entry. Results Based on single cell RNA sequencing data, co-expression of ACE2 and TMPRSS2 was not detected in testicular cells, including sperm. A subpopulation of oocytes in non-human primate ovarian tissue were found to express ACE2 and TMPRSS2, but co-expression was not observed in ovarian somatic cells. RNA expression of TMPRSS2 in 18 samples of human cumulus cells was shown to be low or absent. There was general agreement between publicly available bulk RNA and protein datasets in terms of ACE2 and TMPRSS2 expression patterns in testis, ovary, endometrial and placental cells. Conclusion These analyses suggest that SARS-CoV-2 infection is unlikely to have long-term effects on male and female reproductive function. While the results cannot be considered definitive they imply that procedures in which oocytes are collected and fertilized in vitro are associated with very little risk of viral transmission from gametes to embryos and may indeed have the potential to minimize exposure of susceptible reproductive cell types to infection when compared to natural conception.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1016/j.fertnstert.2020.05.001
bibo:pmid	32622411
has license	els-covid
sha1sum (hex)	ae49ff0f3a762e1a9ab2a606d210025b4a973d1b
schema:url	https://doi.org/10.1016/j.fertnstert.2020.05.001
resource representing a document's title	Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues
has PubMed Central identifier	PMC7205710
has PubMed identifier	32622411
schema:publication	Fertil Steril
resource representing a document's body	covid:ae49ff0f3a762e1a9ab2a606d210025b4a973d1b#body_text
is schema:about of	named entity 'The' named entity 'UNCERTAIN' named entity 'GENE' named entity 'PROTEIN EXPRESSION' named entity 'PROTEINS' named entity 'ASSESSED' named entity 'male' named entity 'protein' named entity 'fertility' named entity 'COVID-19' named entity 'tissues' named entity 'SARS-Cov-2' named entity 'gene and protein expression' named entity 'COVID' named entity 'COVID-19' named entity 'reproductive tissues' named entity 'fertility' named entity 'fertility' named entity 'COVID' named entity 'protease' named entity 'SARS-CoV-2' named entity 'mitochondrial gene' named entity 'cell types' named entity 'CTSL' named entity 'protease' named entity 'pregnancy' named entity 'CatL' named entity 'somatic' named entity 'cell lines' named entity 'cell type' named entity 'cap analysis gene expression' named entity 'Macaca' named entity 'BSG' named entity 'sparse matrix' named entity 'cell types' named entity 'ACE2' named entity 'TMPRSS2' named entity 'protein' named entity 'sperm' named entity 'CTSL' named entity 'ACE2' named entity 'mass spectrometry' named entity 'oocytes' named entity 'co-expression' named entity 'vitro fertilization' named entity 'COVID' named entity 'Pearson correlation' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'RNA' named entity 'mass spectrometry' named entity 'functional activity' named entity 'cumulus cell' named entity 'infection' named entity 'K-nearest neighbor' named entity 'ACE2' named entity 'pregnant women' named entity 'long-term' named entity 'placental tissue' named entity 'cell lines' named entity 'female gamete' named entity 'Pearson correlation' named entity 'feces' named entity 'SARS-CoV-2' named entity 'leydig cells' named entity 'thymus' named entity 'Pearson correlation' named entity 'cell types' named entity 'SARS-Cov-2' named entity 'oocytes' named entity 'oocytes' named entity 'Proteomic'

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