About: Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

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About: Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
Creator	Xu, Jun Chen, Li Feng, Cheng Huang, Fengming Jiang, Chengyu Li, Jianming Li, Jinxiu Liu, Lei Liu, Yingxia Peng, Ling Qin, Yuhao Tan, Shuguang Wang, Fuxiang Wang, Lifei Wang, Zhaoqin Yang, Yang Yin, Lu Yuan, Jing Zhang, Cong Zhang, Zheng Zhao, Dandan Zhou, Congzhao
Source	Medline; PMC
abstract	The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s11427-020-1643-8 and is accessible for authorized users.
has issue date	2020-02-09(xsd:dateTime)
bibo:doi	10.1007/s11427-020-1643-8
bibo:pmid	32048163
has license	no-cc
sha1sum (hex)	addeb2019aeff5d77cfe98578282fccf131d2e65
schema:url	https://doi.org/10.1007/s11427-020-1643-8
resource representing a document's title	Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
has PubMed Central identifier	PMC7088566
has PubMed identifier	32048163
schema:publication	Sci China Life Sci
resource representing a document's body	covid:addeb2019aeff5d77cfe98578282fccf131d2e65#body_text
is schema:about of	named entity 'BIOCHEMICAL' named entity '2019-nCoV' named entity 'VIRAL' named entity 'CLINICAL' named entity 'LUNG INJURY' named entity '2019-NCOV' named entity 'PATIENTS' named entity 'INFECTED' named entity 'INDEXES' named entity 'ground-glass opacity' named entity 'homeostasis' named entity '2019-nCoV' named entity 'virus' named entity 'computed tomography' named entity 'neutrophils' named entity 'myocarditis' named entity 'ARDS' named entity 'Wuhan' named entity 'acute lung injury' named entity 'People's Republic of China' named entity 'sputum production' named entity 'myocarditis' named entity 'left ventricular' named entity '2019-nCoV' named entity 'blood samples' named entity 'fever' named entity 'Pneumonia' named entity 'pneumonia' named entity 'APACHE II' named entity 'poultry' named entity 'APACHE II' named entity 'ARDS' named entity '2019-nCoV' named entity 'super-spreader' named entity 'virus' named entity 'complete blood count' named entity 'Hospital' named entity '2019-nCoV' named entity 'hypoalbuminemia' named entity 'influenza-like' named entity 'Computed tomographic' named entity 'ARDS' named entity 'RNAs' named entity 'plasma' named entity 'LDH' named entity 'Shenzhen' named entity 'albumin' named entity 'complete blood counts' named entity 'biochemical' named entity 'viral load' named entity 'coronavirus' named entity 'fever' named entity '2019-nCoV' named entity '2019-nCoV' named entity 'Shenzhen' named entity 'fever' named entity 'lung' named entity 'ROC curves' named entity '2019-nCoV' named entity '2019-nCoV'

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