About: Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019

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About: Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019
Creator	Ajami, Nadim Cregeen, Sara Petrosino, Joseph Wong, Matthew
Source	BioRxiv; MedRxiv; Medline
abstract	A novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a 96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019.
has issue date	2020-02-13(xsd:dateTime)
bibo:doi	10.1101/2020.02.07.939207
bibo:pmid	32511310
has license	biorxiv
sha1sum (hex)	adb09e4e5c7331b2aa661b3d3bb0a643e00d11bc
schema:url	https://doi.org/10.1101/2020.02.07.939207
resource representing a document's title	Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019
has PubMed identifier	32511310
schema:publication	bioRxiv
resource representing a document's body	covid:adb09e4e5c7331b2aa661b3d3bb0a643e00d11bc#body_text
is schema:about of	named entity 'coronavirus' named entity 'NCOV' named entity 'ORIGIN' named entity 'ISOLATED' named entity 'DECEMBER' named entity 'POSSIBLE' named entity 'CODING SEQUENCE' named entity 'CAUSE' named entity 'WUHAN' named entity 'THESE' named entity 'RECEPTOR BINDING' named entity 'DATASET' named entity 'DETERMINED' named entity 'CORONAVIRUS' named entity 'HIGH' named entity 'ORIGINS' named entity 'EVIDENCE OF' named entity '2019' named entity 'SEQUENCE SIMILARITY' named entity 'GENOME' named entity 'SHARE' named entity 'RBM' named entity 'VIRAL' named entity 'DETECTED' named entity 'RECOMBINATION' named entity '2019' named entity 'PANGOLIN' named entity 'CORONAVIRUSES' named entity 'IDENTIFIED' named entity 'RESPIRATORY ILLNESS' named entity 'RECONSTRUCTED' named entity 'PANGOLINS' named entity 'INDICATING' named entity 'GENOMES' named entity 'DIVERGENCE' named entity 'HUBEI PROVINCE' named entity 'RESEMBLANCE' named entity 'LOW' named entity 'SOURCE' named entity 'MOTIF' named entity 'OUTBREAK' named entity 'GENOMIC' named entity 'CHINA' named entity 'COMPLEX' named entity 'ALTERNATIVE' named entity 'BAT' named entity 'NOVEL CORONAVIRUS' covid:arg/adb09e4e5c7331b2aa661b3d3bb0a643e00d11bc named entity 'coronavirus' named entity '2019' named entity 'high' named entity 'Genomic' named entity '2019' named entity 'analyses' named entity 'isolated' named entity 'receptor binding' named entity 'respiratory illness' named entity 'alternative source' named entity 'sequence similarity' named entity 'Wuhan' named entity 'sequence similarity' named entity 'Hubei Province, China' named entity 'host specificity' named entity 'amino acid' named entity 'amino acid residues' named entity 'ACE2' named entity 'recombination' named entity 'coronavirus' named entity 'receptor binding' named entity 'genome' named entity 'host cell' named entity 'Bat' named entity 'metagenomic' named entity 'RBD' named entity 'protein' named entity 'lung parenchyma' named entity 'amino acid' named entity 'host cell' named entity 'RBD'

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