About: Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicity
Creator	Britton, Paul Keep, Sarah Bickerton, Erica Alrashedi, Hasan Neuman, Benjamin Hall, Ross Maier, Helena
Source	Medline; PMC
abstract	Positive-strand RNA (+RNA) viruses rearrange cellular membranes during replication, possibly in order to concentrate and arrange viral replication machinery for efficient viral RNA synthesis. Our previous work showed that in addition to the conserved coronavirus double membrane vesicles (DMVs), Beau-R, an apathogenic strain of avian Gammacoronavirus infectious bronchitis virus (IBV), induces regions of ER that are zippered together and tethered open-necked double membrane spherules that resemble replication organelles induced by other +RNA viruses. Here we compared structures induced by Beau-R with the pathogenic lab strain M41 to determine whether membrane rearrangements are strain dependent. Interestingly, M41 was found to have a low spherule phenotype. We then compared a panel of pathogenic, mild and attenuated IBV strains in ex vivo tracheal organ culture (TOC). Although the low spherule phenotype of M41 was conserved in TOCs, each of the other tested IBV strains produced DMVs, zippered ER and spherules. Furthermore, there was a significant correlation for the presence of DMVs with spherules, suggesting that these structures are spatially and temporally linked. Our data indicate that virus induced membrane rearrangements are fundamentally linked to the viral replicative machinery. However, coronavirus replicative apparatus clearly has the plasticity to function in different structural contexts.
has issue date	2016-06-03(xsd:dateTime)
bibo:doi	10.1038/srep27126
bibo:pmid	27255716
has license	cc-by
sha1sum (hex)	ada981b0b99f2468f331107ff419b9aea9c9175e
schema:url	https://doi.org/10.1038/srep27126
resource representing a document's title	Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicity
has PubMed Central identifier	PMC4891661
has PubMed identifier	27255716
schema:publication	Sci Rep
resource representing a document's body	covid:ada981b0b99f2468f331107ff419b9aea9c9175e#body_text
is schema:about of	named entity 'FUNCTION' named entity 'REARRANGEMENTS' named entity 'DATA' named entity 'VIRUS' named entity 'STRUCTURAL' named entity 'STRAINS' named entity 'SPHERULE' named entity 'PLASTICITY' named entity 'APPARATUS' named entity 'LOW' named entity 'DIFFERENT' named entity 'PATHOGENIC' named entity 'PHENOTYPE' named entity 'CORRELATION' named entity 'CONTEXTS' named entity 'CORONAVIRUS' named entity 'function' named entity 'organ culture' named entity 'M41' named entity 'panel' named entity 'attenuated' named entity 'viral' named entity 'machinery' named entity 'OPEN' named entity 'determinant' named entity 'CONSERVED' named entity 'INDUCED' named entity 'IBV' named entity 'ATTENUATED' named entity 'COMPARED' named entity 'TRACHEAL' named entity 'REARRANGEMENTS' covid:arg/ada981b0b99f2468f331107ff419b9aea9c9175e named entity 'INDUCED' named entity 'MEMBRANE' named entity 'PATHOGENICITY' named entity 'EXTENSIVE' named entity 'OPEN' named entity 'CORONAVIRUS' named entity 'TESTED' named entity 'LAB' named entity 'DEPENDENT' named entity 'M41' named entity 'DETERMINE' named entity 'MACHINERY' named entity 'STRUCTURES' named entity 'DETERMINANT' named entity 'FOUND' named entity 'MEMBRANE' named entity 'THESE' named entity 'ORGAN CULTURE' named entity 'WAS A' named entity 'STRAIN' named entity 'TOCS' named entity 'VIRAL' named entity 'OUR' named entity 'PANEL' named entity 'MILD' named entity 'EX VIVO' named entity 'PRESENCE OF' named entity 'HAVE' named entity 'SIGNIFICANT' named entity 'correlation' named entity 'DMVs' named entity 'coronavirus' named entity 'mild' named entity 'spherules' named entity 'structures' named entity 'rearrangements' named entity 'IBV' named entity 'TOCs' named entity 'phenotype' named entity 'virus' named entity 'DMVs' named entity 'pathogenicity'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software