About: IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections

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About: IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
Creator	Tang, Yi-Wei Aurelius, Johan Hellstrand, Kristoffer Kabayiza, Jean-Claude Lindh, Magnus Martner, Anna Nilsson, Staffan Rugwizangoga, Belson Prokunina-Olsson, Ludmila Andersson, Maria Nilsson, Malin Sharp, Robert
topic	covid:ad68e5f84b2feb5e50d799f3a1eedf293fb19961#this
Source	Medline; PMC
abstract	Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 ΔG allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract.
has issue date	2019-10-04(xsd:dateTime)
bibo:doi	10.3389/fcimb.2019.00340
bibo:pmid	31637221
has license	cc-by
sha1sum (hex)	ad68e5f84b2feb5e50d799f3a1eedf293fb19961
schema:url	https://doi.org/10.3389/fcimb.2019.00340
resource representing a document's title	IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
has PubMed Central identifier	PMC6787560
has PubMed identifier	31637221
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:ad68e5f84b2feb5e50d799f3a1eedf293fb19961#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ad68e5f84b2feb5e50d799f3a1eedf293fb19961
is schema:about of	named entity 'PREDICT' named entity 'BUT' named entity 'GENOTYPE' named entity 'IFNL4' named entity 'THESE' named entity 'IFNL4' named entity 'RNA VIRUSES' named entity 'PATHOGENS' named entity 'STUDY' named entity 'PREDICTIVE' named entity 'RESPIRATORY TRACT' named entity 'INFORMATION' named entity 'GENE LOCUS' named entity 'SUGGEST' named entity 'HOSPITAL' named entity 'REAL-TIME PCR ' named entity 'VARIATION' named entity 'CHILDREN' named entity 'CLEARANCE' named entity 'GENOTYPES' named entity 'UPPER RESPIRATORY TRACT INFECTIONS' named entity 'RWANDAN' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity 'CHILDREN' named entity 'VISITS' named entity 'RS12979860' named entity 'ABOUT' named entity 'CLEARANCE' named entity 'GENOTYPES' named entity 'ASSOCIATED WITH' named entity 'VARIANTS' named entity 'RWANDAN' named entity 'GENETIC' named entity 'RNA VIRUSES' named entity 'COMMON' named entity 'IMPACT' named entity 'SUBJECTS' named entity 'LATER' named entity 'INTERFERON LAMBDA' named entity 'APPROXIMATELY' named entity 'ALLELE' named entity 'REFERRAL' named entity '480' named entity 'AFRICAN DESCENT' named entity 'HOMOZYGOUS' named entity 'HOST CELL' named entity 'DETERMINE' named entity 'NASOPHARYNGEAL' named entity 'HEPATITIS C VIRUS INFECTION' named entity '2 WEEKS' named entity 'SWABS' named entity 'RESULTS' named entity 'POLYMORPHISMS' named entity 'RESOLUTION' named entity 'MEDICAL CARE' named entity 'INFECTIONS' named entity 'A45' named entity 'OLD' named entity 'REDUCED' named entity 'YEARS' named entity 'POTENTIAL' named entity 'ANALYZED' named entity 'FOLLOW-UP' named entity 'OUR' covid:arg/ad68e5f84b2feb5e50d799f3a1eedf293fb19961 named entity 'genotype' named entity 'infection' named entity 'homozygous'

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