About: Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19)

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19)
Creator	Hoelscher, Michael Thiel, Verena Diefenbach, Max Forster, Felix Guggenbühl Noller, Jessica Kroidl, Inge Olbrich, Laura Pritsch, Michael Radon, Katja Riess, Friedrich Saathoff, Elmar Theis, Fabian Wieser, Andreas
Source	MedRxiv
abstract	Background: The SARS-CoV-2 pandemic is leading to the global introduction of public health interventions to prevent the spread of the virus and avoid the overload of health care systems, especially for the most severely affected patients. Scientific studies to date have focused primarily on describing the clinical course of patients, identifying treatment options and developing vaccines. In Germany, as in many other regions, current tests for SARS-CoV2 are not being conducted on a representative basis and in a longitudinal design. Furthermore, knowledge about the immune status of the population is lacking. Yet these data are needed to understand the dynamics of the pandemic and to thus appropriately design and evaluate interventions. For this purpose, we recently started a prospective population-based cohort in Munich, Germany, with the aim to better understand the state and dynamics of the pandemic. Methods: In 100, randomly selected constituencies out of 755, 3,000 Munich households are identified via random route and offered enrollment into the study. All household members are asked to complete a baseline questionnaire and subjects [≥]14 years of age are asked to provide a venous blood sample of [≤]3 ml for the determination of SARS-CoV-2 IgG/IgA status. The residual plasma and the blood pellet are preserved for later genetic and molecular biological investigations. For twelve months, each household member is asked to keep a diary of daily symptoms, whereabouts and contacts via WebApp. If symptoms suggestive for COVID-19 are reported, family members, including children <14 years, are offered a pharyngeal swab taken at the Division of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, for molecular testing for SARS-CoV-2. In case of severe symptoms, participants will be transferred to a Munich hospital. For one year, the study teams re-visits the households for blood sampling every six weeks. Discussion: With the planned study we will establish a reliable epidemiological tool to improve the understanding of the spread of SARS-CoV-2 and to better assess the effectiveness of public health measures as well as their socio-economic effects. This will support policy makers in managing the epidemic based on scientific evidence.
has issue date	2020-05-02(xsd:dateTime)
bibo:doi	10.1101/2020.04.28.20082743
has license	medrxiv
sha1sum (hex)	acc4b99e98c4bccf45e8baf8491f56ac17bf74ce
schema:url	https://doi.org/10.1101/2020.04.28.20082743
resource representing a document's title	Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19)
resource representing a document's body	covid:acc4b99e98c4bccf45e8baf8491f56ac17bf74ce#body_text
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