About: Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window

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About: Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window
Creator	Barclay, Wendy Howard, Wendy Iqbal, Munir James, Joe Shelton, Holly Nair, Venugopal
source	PMC
abstract	Avian influenza is a significant economic burden on the poultry industry in geographical regions where it is enzootic. It also poses a public health concern when avian influenza subtypes infect humans, often with high mortality. Understanding viral genetic factors which positively contribute to influenza A virus (IAV) fitness – infectivity, spread and pathogenesis – is of great importance both for human and livestock health. PB1-F2 is a small accessory protein encoded by IAV and in mammalian hosts has been implicated in a wide range of functions that contribute to increased pathogenesis. In the avian host, the protein has been understudied despite high-level full-length conservation in avian IAV isolates, which is in contrast to the truncations of the PB1-F2 length frequently found in mammalian host isolates. Here we report that the presence of a full-length PB1-F2 protein, from a low pathogenicity H9N2 avian influenza virus, prolongs infectious virus shedding from directly inoculated chickens, thereby enhancing transmission of the virus by lengthening the transmission window to contact birds. As well as extending transmission, the presence of a full-length PB1-F2 suppresses pathogenicity evidenced by an increased minimum lethal dose in embryonated chicken eggs and increasing survival in directly infected birds when compared to a virus lacking an ORF for PB1-F2. We propose that there is a positive pressure to maintain a full-length functional PB1-F2 protein upon infection of avian hosts as it contributes to the effective transmission of IAV in the field.
has issue date	2016-10-13(xsd:dateTime)
bibo:doi	10.1099/jgv.0.000584
bibo:pmid	27558742
has license	cc-by
sha1sum (hex)	ac8d2e900ee0c6d713d153782a530ddee6d606aa
schema:url	https://doi.org/10.1099/jgv.0.000584
resource representing a document's title	Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window
has PubMed Central identifier	PMC5078828
has PubMed identifier	27558742
schema:publication	J Gen Virol
resource representing a document's body	covid:ac8d2e900ee0c6d713d153782a530ddee6d606aa#body_text
is schema:about of	named entity 'Understanding' named entity 'length' named entity 'infect' named entity 'poultry industry' named entity 'IAV' named entity 'presence' named entity 'Here' named entity 'influenza A virus' named entity 'health' named entity 'eggs' named entity 'PROTEIN ' named entity 'LENGTHENING' named entity 'PB1-F2 PROTEIN' named entity 'INFECTION' named entity 'TABLES' named entity 'INFECTIOUS' named entity 'REPORT' named entity 'HOST' named entity 'LIVESTOCK' named entity 'CHICKENS' named entity 'GENETIC FACTORS' named entity 'ISOLATES' named entity 'VIRUS' named entity 'PROTEIN ' named entity 'FIGURE' named entity 'EGGS' named entity 'AVIAN INFLUENZA VIRUS' named entity 'SIGNIFICANT' named entity 'PB1-F2 PROTEIN' named entity 'EXTENDING' named entity 'FUNCTIONS' named entity 'TRANSMISSION' named entity 'TO MAINTAIN' named entity 'PRESENCE OF' named entity 'ENCODED' named entity 'SURVIVAL' named entity 'GREAT' named entity 'AVIAN' named entity 'GEOGRAPHICAL REGIONS' named entity 'HOSTS' named entity 'HUMAN' named entity 'CONTRIBUTE ' named entity 'WINDOW' named entity 'UNDERSTANDING' named entity 'SUPPLEMENTARY MATERIAL' named entity 'LACKING' named entity 'FUNCTIONAL' named entity 'LENGTHENING' named entity 'POSITIVE' named entity 'PB1-F2' named entity 'ONLINE' named entity 'HEALTH' named entity 'ORF' named entity 'WHERE' named entity 'PROLONGS' named entity 'PUBLIC HEALTH' named entity 'EFFECTIVE' named entity 'SPREAD' named entity 'COMPARED' named entity 'INCREASED' named entity 'TO CONTACT' named entity 'AVAILABLE' named entity 'INFECTED' named entity 'ACCESSORY PROTEIN' named entity 'VIRAL SHEDDING' named entity 'LEVEL' named entity 'MINIMUM' named entity 'WINDOW' named entity 'TRANSMISSION' named entity 'CHICKENS' named entity 'INFLUENZA A VIRUS' named entity 'HIGH' named entity 'BIRDS' named entity 'IS A' named entity 'CONSERVATION' named entity 'AVIAN INFLUENZA'

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