About: Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

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About: Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Creator	Fouchier, Ron Osterhaus, Albert Thiel, Volker Dijkman, Ronald Drosten, Christian Rottier, Peter Muth, Doreen Mou, Huihui Haagmans, Bart Müller, Marcel Berend, Jan Bosch, Smits, Saskia Stalin Raj, V Zaki, Ali Dekkers, Dick Demmers, Jeroen
Source	Medline; PMC
abstract	Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals(1). However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of systemic spread(2). Recently, another coronavirus (human coronavirus-Erasmus Medical Center (hCoV-EMC)) was identified in patients with severe and sometimes lethal lower respiratory tract infection(3,4). Viral genome analysis revealed close relatedness to coronaviruses found in bats(5). Here we identify dipeptidyl peptidase 4 (DPP4; also known as CD26) as a functional receptor for hCoV-EMC. DPP4 specifically co-purified with the receptor-binding S1 domain of the hCoV-EMC spike protein from lysates of susceptible Huh-7 cells. Antibodies directed against DPP4 inhibited hCoV-EMC infection of primary human bronchial epithelial cells and Huh-7 cells. Expression of human and bat (Pipistrellus pipistrellus) DPP4 in non-susceptible COS-7 cells enabled infection by hCoV-EMC. The use of the evolutionarily conserved DPP4 protein from different species as a functional receptor provides clues about the host range potential of hCoV-EMC. In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nature12005) contains supplementary material, which is available to authorized users.
has issue date	2013-03-13(xsd:dateTime)
bibo:doi	10.1038/nature12005
bibo:pmid	23486063
has license	no-cc
sha1sum (hex)	ac25bd72e693215c9be92673f2ff7d927b052ecf
schema:url	https://doi.org/10.1038/nature12005
resource representing a document's title	Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
has PubMed Central identifier	PMC7095326
has PubMed identifier	23486063
schema:publication	Nature
resource representing a document's body	covid:ac25bd72e693215c9be92673f2ff7d927b052ecf#body_text
is schema:about of	named entity 'HUMAN CORONAVIRUS' named entity 'IS A' named entity 'RECEPTOR' named entity 'DIPEPTIDYL PEPTIDASE 4' named entity 'EMC' named entity 'FUNCTIONAL' named entity 'functional' named entity 'receptor' named entity 'cell surface receptor' named entity 'bat' named entity 'enzyme' named entity 'bat' named entity 'protein' named entity 'antiserum' named entity 'bat' named entity 'eluent' named entity 'NSP4' named entity 'coronaviruses' named entity 'DPP4' named entity 'ACE2' named entity 'antiserum' named entity 'precleared' named entity 'downregulation' named entity 'Coronaviruses' named entity 'cytopathic effects' named entity 'TaqMan' named entity 'infection' named entity 'cell lysates' named entity 'serum' named entity 'ACE2' named entity 'expression vector' named entity 'cell adhesion molecules' named entity 'FITC' named entity 'receptor' named entity 'hormones' named entity 'kDa' named entity 'DPP4' named entity 'ACE2' named entity 'prostate' named entity 'bat' named entity 'receptor' named entity 'aminopeptidase' named entity 'DPP4' named entity 'SARS-CoV' named entity 'DPP4' named entity 'cross-reactive' named entity 'plasmid' named entity 'DPP4' named entity 'Huh-7' named entity 'supernatant' named entity 'transfection' named entity 'SARS-CoV' named entity '293T cells' named entity 'lower respiratory tract' named entity 'human coronavirus' named entity 'antibodies' named entity 'DPP4' named entity 'Vero cells' named entity 'protein' named entity 'Taqman' named entity 'human coronavirus' named entity 'ciliated cells' named entity 'antiserum' named entity 'Pipistrellus pipistrellus' named entity 'peptides'

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