About: The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection

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About: The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection
Creator	Qi, Jing Zhou, Yang Hua, Jiao Bian Msc, Jialin Liu Msc, Beibei Phd, Shuilin Zhang Msc, Liying Zhao Msc, Zicen
Source	BioRxiv
abstract	Background COVID-19 caused by SARA-CoV-2 is a disaster sweeping over 200 countries, and more than 2,150,000 people are suffering from the disease and 140,000 people died. ACE2 is a receptor protein of SARS- CoV-2, and TMPRSS2 promotes virus proliferation and transmission. Some patients developed multiple organ dysfunction syndromes other than lungs. Therefore, studying the viral susceptibility of other organs is important for a deeper understanding of viral pathogenesis. Methods The advantage of scRNA-seq data is the identification of cell types by clustering the gene expression of cells. ACE2 and TMPRSS2 are highly expressed in AT2 of lungs, we compared the ACE2 and TMPRSS2 expression levels of cell types from 31 organs, with AT2 of lungs to evaluate the risk of the viral infection using scRNA-seq data. Findings For the first time, we found the brain, gall bladder, and fallopian tube are vulnerable to COVID-19 infection. Besides, the nose, heart, small intestine, large intestine, esophagus, testis and kidney are also identified to be high-risk organs with high expression levels of ACE2 and TMPRSS2. Moreover, the susceptible organs are grouped into three risk levels based on the TMPRSS2 expression. As a result, the respiratory system, digestive system and reproductive system are at the top-risk level to COVID-19 infection. Interpretation This study provides evidence for COVID-19 infection in the human nervous system, digestive system, reproductive system, respiratory system, circulatory system and urinary system using scRNA-seq data, which helps for the clinical diagnosis and treatment of patients.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1101/2020.04.16.045690
has license	biorxiv
sha1sum (hex)	ab99db9d55a4540a835e8d043f919306be53cc1c
schema:url	https://doi.org/10.1101/2020.04.16.045690
resource representing a document's title	The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection
schema:publication	bioRxiv
resource representing a document's body	covid:ab99db9d55a4540a835e8d043f919306be53cc1c#body_text
is schema:about of	named entity 'COVID-19' named entity 'protease' named entity 'TMPRSS2' named entity 'PROVIDES EVIDENCE FOR' named entity 'TREATMENT' named entity 'HELPS' named entity 'CIRCULATORY SYSTEM' named entity 'SCRNA-SEQ' named entity 'data' named entity 'evidence' named entity 'patients' named entity 'reproductive system' named entity 'cellular' named entity 'COVID-19 infection' named entity 'TMPRSS2' named entity 'infection' named entity 'acute respiratory infection' named entity 'type II alveolar cells' named entity 'scRNA-seq' named entity 'lung' named entity 'data analysis' named entity 'thyroid gland' named entity 'oligodendrocyte precursor cells' named entity 'high-risk' named entity 'bronchus' named entity 'nasal turbinate' named entity 'oligodendrocyte precursor cells' named entity 'data analysis' named entity 'duodenum' named entity 'expression levels' named entity 'clinical symptoms' named entity 'epithelial cells' named entity 'ACE2' named entity 'high-risk' named entity 'somatic cells' named entity 'infection' named entity 'testis' named entity 'fallopian tube' named entity 'gall bladder' named entity 'airway epithelium' named entity 'endothelial cells' named entity 'colon' named entity 'ileum' named entity 'scRNA-seq' named entity 'kidney' named entity 'ACE2' named entity 'kidney' named entity 'peripheral blood' named entity 'ileum' named entity 'spleen' named entity 'scRNA-seq' named entity 'lung' named entity 'bladder' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'fallopian tube' named entity 'infection' named entity 'infection' named entity 'gene expression' named entity 'uterus' named entity 'scRNA-seq' named entity 'epithelial cells' named entity 'human systems' named entity 'jejunum' named entity 'ACE2' named entity 'nephron' named entity 'epithelium' named entity 'human organs' named entity 'gross anatomical' named entity 'epithelial cells' named entity 'primordium' named entity 'fallopian tube' named entity 'COVID' named entity 'TMPRSS2' named entity 'data analysis' named entity 'kidney' named entity 'high-risk'

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