About: Acute gastrointestinal injury in critically ill patients with coronavirus disease 2019 in Wuhan, China

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About: Acute gastrointestinal injury in critically ill patients with coronavirus disease 2019 in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute gastrointestinal injury in critically ill patients with coronavirus disease 2019 in Wuhan, China
Creator	Gu, Wei Li, Jing-Jing Chen, Jiu-Dong Kan, Xiao-Hua Liu, Qi, Jian-Wei Shi, Qian-Kun Sun, Jia-Kui Yuan, Shou-Tao Zhang, Zou,
topic	covid:ab7999966605546c679e273912bf3b5c52a27c48#this
Source	MedRxiv
abstract	Background: To investigate the prevalence and outcomes of acute gastrointestinal injury (AGI) in critically ill patients with coronavirus disease 2019 (COVID-19). Methods: In this clinical retrospective study, demographic data, laboratory parameters, AGI grades, clinical severity and outcomes were collected. The primary endpoints were AGI incidence and 28-day mortality, the secondary endpoints were organ dysfunction and septic shock incidence. Results: From February 10 to March 10 2020, 83 critically ill patients of 1314 patients with COVID-19 were enrolled. Seventy-two (86.7%) patients had AGI during hospital stay, of them, 30 had AGI grade I, 35 had AGI grade II, 5 had AGI grade III, and 2 had AGI grade IV. The incidence of AGI grade II and above was 50.6%. As of March 16, 40 (48.2%) patients died within 28 days of admission, the median hospital stay was 12.0 days, ranging from 3 days to 27 days. Multiple organ dysfunction syndrome developed in 58 (69.9%) patients, septic shock in 16 (19.3%) patients. Patients with worse AGI grades had worse clinical variables, higher septic shock incidence and 28-day mortality. Sequential organ failure assessment scores (SOFA) (95% CI, 1.374-2.860; P <0.001), white blood cell (WBC) counts (95% CI, 1.037-1.379; P =0.014), duration of mechanical ventilation (MV) (95% CI, 1.020-1.340; P =0.025) were risk factors for the development of AGI grade II and above. Non-survivors were accompanied by higher incidence of AGI grade III to IV than survivors (17.5% vs. 0.0%, P =0.004). Conclusions: The AGI incidence was 86.7%, and hospital mortality was 48.2% in critically ill patients with COVID-19. SOFA scores, WBC counts, and duration of MV were risk factors for the development of AGI grade II and above. Patients with worse AGI grades had worse clinical severity variables, higher septic shock incidence and 28-day mortality.
has issue date	2020-03-27(xsd:dateTime)
bibo:doi	10.1101/2020.03.25.20043570
has license	medrxiv
sha1sum (hex)	ab7999966605546c679e273912bf3b5c52a27c48
schema:url	https://doi.org/10.1101/2020.03.25.20043570
resource representing a document's title	Acute gastrointestinal injury in critically ill patients with coronavirus disease 2019 in Wuhan, China
resource representing a document's body	covid:ab7999966605546c679e273912bf3b5c52a27c48#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ab7999966605546c679e273912bf3b5c52a27c48
is schema:about of	named entity 'China' named entity 'PREVALENCE' named entity 'GASTROINTESTINAL INJURY' named entity 'BACKGROUND' named entity 'AGI' named entity 'prevalence' named entity 'injury' named entity 'coronavirus disease 2019' named entity 'China' named entity 'Wuhan' named entity 'coronavirus disease 2019' named entity 'critically ill patients' named entity 'critically ill patients' named entity 'gastrointestinal' covid:arg/ab7999966605546c679e273912bf3b5c52a27c48 named entity 'GASTROINTESTINAL INJURY' named entity 'PATIENTS' named entity 'ACUTE' named entity 'CRITICALLY ILL' named entity 'CORONAVIRUS DISEASE 2019' named entity 'gastrointestinal' named entity 'gastrointestinal' named entity 'critically ill' named entity 'acute' named entity 'patients' named entity 'investigate' named entity 'Wuhan' named entity 'coronavirus disease 2019' named entity 'CORONAVIRUS DISEASE 2019' named entity 'patients' named entity 'injury' named entity 'CRITICALLY ILL' named entity 'TO INVESTIGATE' named entity 'OUTCOMES' named entity 'gastrointestinal' named entity 'critically ill' named entity 'coronavirus disease 2019' named entity 'ACUTE' named entity 'PATIENTS' named entity 'WUHAN' named entity 'CHINA' nodeID://b56407294 nodeID://b56417678 nodeID://b56440258 nodeID://b56526806 nodeID://b56526838 nodeID://b56529182 nodeID://b56651238 nodeID://b56655786 nodeID://b56697070 nodeID://b56704442 nodeID://b56794962 nodeID://b56794982 nodeID://b56815350 nodeID://b56836222 nodeID://b56925442 nodeID://b56942426 nodeID://b57046706 nodeID://b57053546 nodeID://b57074294 nodeID://b57111530 nodeID://b57128698 nodeID://b57141910 nodeID://b57165146 nodeID://b57279886 nodeID://b57280754 nodeID://b57288266 nodeID://b57342566 nodeID://b57342590 nodeID://b57362914 nodeID://b57378542 nodeID://b57378566 nodeID://b57397590

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