About: Core Outcomes Set for Trials in People With Coronavirus Disease 2019

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Core Outcomes Set for Trials in People With Coronavirus Disease 2019
Creator	Torres, Antoni Webb, Steve Povoa, Pedro Horby, Peter Lee, Jaehee Mehta, Sangeeta Zhang, Junhua Sakr, Yasser Smyth, Alan Mphil, Shen, ; Woc-Colburn, Laila Baumgart, Amanda Bersten, Andrew Cervantes, Lilia Chew, Derek Cho, Yeoungjee Cooper, Tess Craig, Jonathan Crowe, Sally Douglas, Ivor Elliott, Julian Evangelidis, Nicole Flemyng, Ella Hannan, Elyssa John, ; Liu, Emma Lorca, Eduardo Lynch, Deena Manera, Karine Org, Www Teixeira-Pinto, Armando Tong, Allison Turner, Tari Viecelli, Andrea Williamson, Paula Andrew, ; Azevedo, Cesar Luciano, ; Marshall, C Mckenzie, Anne Mcleod, Charlie Mervyn Mer, ; Morris, Conway Reid, ; Saad Nseir, ; Snelling, ; Andrea, ; Giovanni, ; Gonzalez, Matus Howell, ; Qld, Australia Society, Jonze Strippoli, F
Source	Medline; PMC
abstract	OBJECTIVES: The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop was to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019. DESIGN: Four international online multistakeholder consensus workshops were convened to discuss proposed core outcomes for trials in people with suspected or confirmed coronavirus disease 2019, informed by a survey involving 9,289 respondents from 111 countries. The transcripts were analyzed thematically. The workshop recommendations were used to finalize the core outcomes set. SETTING: International. SUBJECTS: Adults 18 years old and over with confirmed or suspected coronavirus disease 2019, their family members, members of the general public and health professionals (including clinicians, policy makers, regulators, funders, researchers). INTERVENTIONS: None. MEASUREMENTS: None. MAIN RESULTS: Six themes were identified. “Responding to the critical and acute health crisis” reflected the immediate focus on saving lives and preventing life-threatening complications that underpinned the high prioritization of mortality, respiratory failure, and multiple organ failure. “Capturing different settings of care” highlighted the need to minimize the burden on hospitals and to acknowledge outcomes in community settings. “Encompassing the full trajectory and severity of disease” was addressing longer term impacts and the full spectrum of illness (e.g. shortness of breath and recovery). “Distinguishing overlap, correlation and collinearity” meant recognizing that symptoms such as shortness of breath had distinct value and minimizing overlap (e.g. lung function and pneumonia were on the continuum toward respiratory failure). “Recognizing adverse events” refers to the potential harms of new and evolving interventions. “Being cognizant of family and psychosocial wellbeing” reflected the pervasive impacts of coronavirus disease 2019. CONCLUSIONS: Mortality, respiratory failure, multiple organ failure, shortness of breath, and recovery are critically important outcomes to be consistently reported in coronavirus disease 2019 trials.
has issue date	2020-08-25(xsd:dateTime)
bibo:doi	10.1097/ccm.0000000000004585
bibo:pmid	32804792
has license	cc-by
sha1sum (hex)	ab72b33cacf766b2baed6dd304bdfcebd1b42a91
schema:url	https://doi.org/10.1097/ccm.0000000000004585
resource representing a document's title	Core Outcomes Set for Trials in People With Coronavirus Disease 2019
has PubMed Central identifier	PMC7448717
has PubMed identifier	32804792
schema:publication	Crit Care Med
resource representing a document's body	covid:ab72b33cacf766b2baed6dd304bdfcebd1b42a91#body_text
is schema:about of	named entity 'Trials' named entity 'Critical Care Medicine' named entity '2019' named entity 'Critical Care' named entity 'respiratory support' named entity 'life-threatening' named entity 'respiratory support' named entity 'lung disease' named entity 'pulmonary fibrosis' named entity 'psychosocial' named entity 'depression' named entity 'x-ray' named entity 'Respiratory failure' named entity 'Shortness of breath' named entity 'kidney damage' named entity 'adverse events' named entity 'sepsis' named entity 'Multiple organ failure' named entity 'Respiratory failure' named entity 'acute kidney injury' named entity 'health professionals' named entity 'COVID-19' named entity 'hydroxychloroquine' named entity 'COVID-19' named entity 'invited people' named entity 'multiple organ failure' named entity 'shortness of breath' named entity 'respiratory failure'

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