About: Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications

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About: Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications
Creator	Ae, Manuel
Source	PMC
abstract	In metazoans apoptosis is a major physiological process of cell elimination during development and in tissue homeostasis and can be involved in pathological situations. In vitro, apoptosis proceeds through an execution phase during which cell dismantling is initiated, with or without fragmentation into apoptotic bodies, but with maintenance of a near-to-intact cytoplasmic membrane, followed by a transition to a necrotic cell elimination traditionally called “secondary necrosis”. Secondary necrosis involves activation of self-hydrolytic enzymes, and swelling of the cell or of the apoptotic bodies, generalized and irreparable damage to the cytoplasmic membrane, and culminates with cell disruption. In vivo, under normal conditions, the elimination of apoptosing cells or apoptotic bodies is by removal through engulfment by scavengers prompted by the exposure of engulfment signals during the execution phase of apoptosis; if this removal fails progression to secondary necrosis ensues as in the in vitro situation. In vivo secondary necrosis occurs when massive apoptosis overwhelms the available scavenging capacity, or when the scavenger mechanism is directly impaired, and may result in leakage of the cell contents with induction of tissue injury and inflammatory and autoimmune responses. Several disorders where secondary necrosis has been implicated as a pathogenic mechanism will be reviewed.
has issue date	2008-03-06(xsd:dateTime)
bibo:doi	10.1007/s10495-008-0187-8
bibo:pmid	18322800
has license	no-cc
sha1sum (hex)	aa9c1f389dc07f0d30ea91c46a4b96aaa5056c0c
schema:url	https://doi.org/10.1007/s10495-008-0187-8
resource representing a document's title	Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications
has PubMed Central identifier	PMC7102248
has PubMed identifier	18322800
schema:publication	Apoptosis
resource representing a document's body	covid:aa9c1f389dc07f0d30ea91c46a4b96aaa5056c0c#body_text
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