About: Negri bodies and other virus membrane-less replication compartments()

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Negri bodies and other virus membrane-less replication compartments() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Negri bodies and other virus membrane-less replication compartments()
Creator	Nevers, Quentin Gaudin, Yves Albertini, Aurélie Lagaudrière-Gesbert, Cécile
source	Elsevier; Medline; PMC
abstract	Viruses reshape the organization of the cell interior to achieve different steps of their cellular cycle. Particularly, viral replication and assembly often take place in viral factories where specific viral and cellular proteins as well as nucleic acids concentrate. Viral factories can be either membrane-delimited or devoid of any cellular membranes. In the latter case, they are referred as membrane-less replication compartments. The most emblematic ones are the Negri bodies, which are inclusion bodies that constitute the hallmark of rabies virus infection. Interestingly, Negri bodies and several other viral replication compartments have been shown to arise from a liquid-liquid phase separation process and, thus, constitute a new class of liquid organelles. This is a paradigm shift in the field of virus replication. Here, we review the different aspects of membrane-less virus replication compartments with a focus on the Mononegavirales order and discuss their interactions with the host cell machineries and the cytoskeleton. We particularly examine the interplay between viral factories and the cellular innate immune response, of which several components also form membrane-less condensates in infected cells.
has issue date	2020-08-21(xsd:dateTime)
bibo:doi	10.1016/j.bbamcr.2020.118831
bibo:pmid	32835749
has license	no-cc
sha1sum (hex)	aa43180ea5bd68029968cac66e6fd093b1e7f9d9
schema:url	https://doi.org/10.1016/j.bbamcr.2020.118831
resource representing a document's title	Negri bodies and other virus membrane-less replication compartments()
has PubMed Central identifier	PMC7442162
has PubMed identifier	32835749
schema:publication	Biochim Biophys Acta Mol Cell Res
resource representing a document's body	covid:aa43180ea5bd68029968cac66e6fd093b1e7f9d9#body_text
is schema:about of	named entity 'viral' named entity 'Journal' named entity '2017' named entity 'interior' named entity 'Viral' named entity 'steps' named entity 'Here' named entity 'Science' named entity 'virus' named entity 'separation process' named entity 'cell' named entity 'rapidly' named entity 'wide range' named entity 'This' named entity 'virus' named entity 'SENSITIVE TO' named entity 'FOCUS' named entity 'SARS-COV-2' named entity 'NUCLEUS' named entity 'THEIR' named entity 'NUCLEIC ACIDS' named entity 'INNATE IMMUNITY' named entity 'SEPARATION PROCESS' named entity 'LIQUID' named entity 'CELL INTERIOR' named entity 'COMPARTMENT' named entity 'STRUCTURE' named entity 'CELL PROCESSES' named entity 'IS A' named entity 'REVIEW' named entity 'Journal' named entity 'liquid' named entity 'machineries' named entity 'factories' named entity 'nucleus' named entity 'Journal' named entity 'interferon' named entity 'organelles' named entity 'Journal' named entity 'cellular membranes' named entity 'physicochemical' named entity 'cytoskeleton' named entity 'organelle' named entity 'nucleic acids' named entity 'field' named entity 'essential' named entity 'environment' named entity 'involved' named entity 'factors' named entity 'virus' named entity 'replication' named entity 'Vesicular stomatitis virus' named entity 'Stress granules' named entity 'Viral factories' named entity 'liquid phase' named entity 'Negri bodies' named entity 'interferon' named entity 'Respiratory syncytial virus' named entity 'Viral replication' named entity 'nucleic acids' named entity 'organelle' named entity 'innate immunity' named entity 'nucleoli' named entity 'dynamic structures' named entity 'VSV' named entity 'viral replication' named entity 'cytoskeleton' named entity 'virus' named entity 'virus' named entity 'case' named entity 'nuclear speckles' named entity 'Glu' named entity 'Rhabdovirus' named entity 'RNA' named entity 'Paramyxovirus' named entity 'IFN' named entity 'leader RNA' named entity 'HSV-1'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software