About: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates

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About: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
Creator	Teeling, Emma Koepfli, Klaus-Peter Zhao, Huabin Lindblad-Toh, Kerstin Karlsson, Elinor Painter, Corrie Corbo, Marco Damas, Joana Genereux, Diane Hiller, Michael Hughes, Graham Keough, Kathleen Lewin, Harris Nweeia, Martin Persky, Nicole Pfenning, Andreas Pollard, Katherine Ryder, Oliver Swofford, Ross
source	BioRxiv; Medline
abstract	The novel coronavirus SARS-CoV-2 is the cause of Coronavirus Disease-2019 (COVID-19). The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of 410 vertebrates, including 252 mammals, to study cross-species conservation of ACE2 and its likelihood to function as a SARS-CoV-2 receptor. We designed a five-category ranking score based on the conservation properties of 25 amino acids important for the binding between receptor and virus, classifying all species from very high to very low. Only mammals fell into the medium to very high categories, and only catarrhine primates in the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 binding, and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (<0.1%) variants in 10/25 binding sites. In addition, we observed evidence of positive selection in ACE2 in multiple species, including bats. Utilized appropriately, our results may lead to the identification of intermediate host species for SARS-CoV-2, justify the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care.
has issue date	2020-04-18(xsd:dateTime)
bibo:doi	10.1101/2020.04.16.045302
bibo:pmid	32511356
has license	biorxiv
sha1sum (hex)	a9ab4537c3ddad7efce17cfad8e775f1c8600d6f
schema:url	https://doi.org/10.1101/2020.04.16.045302
resource representing a document's title	Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
has PubMed identifier	32511356
schema:publication	bioRxiv
resource representing a document's body	covid:a9ab4537c3ddad7efce17cfad8e775f1c8600d6f#body_text
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