About: Minireview of progress in the structural study of SARS-CoV-2 proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Minireview of progress in the structural study of SARS-CoV-2 proteins
Creator	Zhu, Yun Sun, Fei Zhu, Chunmei Zhu, Guoliang
source	Elsevier; PMC
abstract	Abstract A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization, broke out in China and rapidly developed into a global pandemic, with millions of cases and hundreds of thousands of deaths reported globally. The novel coronavirus, which was designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified as the etiological agent of COVID-19. On the basis of experience accumulated following previous SARS-CoV and MERS-CoV outbreaks and research, a series of studies have been conducted rapidly, and major progress has been achieved with regard to the understanding of the phylogeny and genomic organization of SARS-CoV-2 in addition its molecular mechanisms of infection and replication. In the present review, we summarized crucial developments in the elucidation of the structure and function of key SARS-CoV-2 proteins, especially the main protease, RNA-dependent RNA polymerase, spike glycoprotein, and nucleocapsid protein. Results of studies on their associated inhibitors and drugs have also been highlighted.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1016/j.crmicr.2020.06.003
has license	els-covid
sha1sum (hex)	a9a11559d8f8a9af8ab2d880e1e4c7b4c15ac6b0
schema:url	https://doi.org/10.1016/j.crmicr.2020.06.003
resource representing a document's title	Minireview of progress in the structural study of SARS-CoV-2 proteins
has PubMed Central identifier	PMC7323663
resource representing a document's body	covid:a9a11559d8f8a9af8ab2d880e1e4c7b4c15ac6b0#body_text
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