About: Infectious entry of equine herpesvirus-1 into host cells through different endocytic pathways

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About: Infectious entry of equine herpesvirus-1 into host cells through different endocytic pathways Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectious entry of equine herpesvirus-1 into host cells through different endocytic pathways
Creator	Kimura, Takashi Sasaki, Michihito Sawa, Hirofumi Umemura, Takashi Hasebe, Rie Wada, Ryuichi
Source	Elsevier; Medline; PMC
abstract	Abstract We investigated the mechanism by which equine herpesvirus-1 (EHV-1) enters primary cultured equine brain microvascular endothelial cells (EBMECs) and equine dermis (E. Derm) cells. EHV-1 colocalized with caveolin in EBMECs and the infection was greatly reduced by the expression of a dominant negative form of equine caveolin-1 (ecavY14F), suggesting that EHV-1 enters EBMECs via caveolar endocytosis. EHV-1 entry into E. Derm cells was significantly reduced by ATP depletion and treatments with lysosomotropic agents. Enveloped virions were detected from E. Derm cells by infectious virus recovery assay after viral internalization, suggesting that EHV-1 enters E. Derm cells via energy- and pH-dependent endocytosis. These results suggest that EHV-1 utilizes multiple endocytic pathways in different cell types to establish productive infection.
has issue date	2009-10-25(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.07.032
bibo:pmid	19720389
has license	els-covid
sha1sum (hex)	a948d3d1edcc5f8010e4787c340927a7e9f3982f
schema:url	https://doi.org/10.1016/j.virol.2009.07.032
resource representing a document's title	Infectious entry of equine herpesvirus-1 into host cells through different endocytic pathways
has PubMed Central identifier	PMC7111996
has PubMed identifier	19720389
schema:publication	Virology
resource representing a document's body	covid:a948d3d1edcc5f8010e4787c340927a7e9f3982f#body_text
is schema:about of	named entity 'caveolin' named entity 'ATP' named entity 'cells' named entity 'enters' named entity 'Infectious' named entity 'cells' named entity 'GREATLY' named entity 'DETECTED' named entity 'FORM' named entity 'ATP DEPLETION' named entity 'REDUCED' named entity 'DOMINANT NEGATIVE' named entity 'CELLS' named entity 'EXPRESSION' named entity 'VIRUS' named entity 'BRAIN' named entity 'VIRAL' named entity 'INFECTION' named entity 'EQUINE HERPESVIRUS-1' named entity 'PRIMARY' named entity 'SUGGEST' named entity 'DERM' named entity 'VIRIONS' named entity 'MECHANISM' named entity 'PATHWAYS' named entity 'CELL TYPES' named entity 'PH-' named entity 'ENDOCYTOSIS' named entity 'EQUINE' named entity 'TREATMENTS' named entity 'DIFFERENT' named entity 'EQUINE HERPESVIRUS-1' named entity 'RESULTS' named entity 'ENTRY' named entity 'HOST CELLS' named entity 'PATHWAYS' named entity 'INFECTIOUS' named entity 'PRODUCTIVE' named entity 'MULTIPLE' named entity 'ENTRY' named entity 'INVESTIGATED' named entity 'ASSAY' named entity 'INTERNALIZATION' named entity 'CAVEOLIN-1' named entity 'MICROVASCULAR' named entity 'ENDOTHELIAL CELLS' named entity 'ENERGY' named entity 'DEPENDENT' named entity 'ESTABLISH' named entity 'DIFFERENT' named entity 'DERMIS' named entity 'THESE' named entity 'CULTURED' named entity 'INFECTIOUS' named entity 'CAVEOLIN' named entity 'RECOVERY' covid:arg/a948d3d1edcc5f8010e4787c340927a7e9f3982f named entity 'Derm' named entity 'infection' named entity 'expression' named entity 'cell types' named entity 'agents' named entity 'reduced' named entity 'Derm' named entity 'Derm' named entity 'assay' named entity 'equine' named entity 'infection' named entity 'equine' named entity 'herpesvirus' named entity 'endocytic' named entity 'assay' named entity 'brain microvascular' named entity 'equine herpesvirus' named entity 'host cells' named entity 'dermis'

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