About: Obesity is Associated with Reduced Brain Tissue Oxygen Tension After Severe Brain Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Obesity is Associated with Reduced Brain Tissue Oxygen Tension After Severe Brain Injury
Creator	Butler, Christi Chanderraj, Rishi Faerber, Jennifer Frangos, Suzanne Gant, Ryan Kofke, • Kumar, Monisha Leroux, Peter Levine, Joshua Maloney-Wilensky, Eileen
Source	PMC
abstract	BACKGROUND: Obesity has been associated with compromised tissue oxygenation and reduced organ perfusion. The brain is critically dependent on oxygen delivery, and reduced brain tissue oxygen tension (P(bt)O(2)) may result in poor outcome after brain injury. We tested the hypothesis that obesity is associated with compromised P(bt)O(2) after severe brain injury. METHODS: Patients with severe brain injury (GCS score ≤ 8) who underwent continuous P(bt)O(2) monitoring were retrospectively identified from a prospective single-center database. Patients, were classified by body mass index (BMI = weight (kg)/m(2)) and were included if they were obese (BMI ≥ 30) or non-obese (BMI = <30). RESULTS: Sixty-nine patients (mean age 46.4 ± 17.0 years) were included. Mean daily P(bt)O(2) was 25.8 (9.6) mmHg for the 28 obese and 31.8 (12.3) mmHg for the 41 non-obese patients (P = 0.03). Initial P(bt)O(2) and mean daily maximum P(bt)O(2) measurements also were significantly lower in obese patients than in non-obese patients. Univariate predictors of compromised P(bt)O(2) (defined as minutes P(bt)O(2) < 20 mmHg) included elevated BMI (P = 0.02), presence of ARDS (P < 0.01), mean PaO(2) (P < 0.01), maximum FiO(2) (P < 0.01), mean PaO(2):FiO(2) (P < 0.01), and mean CVP (P < 0.01). In multivariable analysis, BMI was significantly associated with compromised P(bt)O(2) (P = 0.02). Sex, age, and mean CVP were also identified as significant predictors of compromised P(bt)O(2); ARDS and PF ratio were not. CONCLUSIONS: In patients with severe brain injury, obesity was found to be an independent predictor of compromised P(bt)O(2). This effect may be mediated through obesity-related pulmonary dysfunction and inadequate compensatory mechanisms.
has issue date	2011-07-12(xsd:dateTime)
bibo:doi	10.1007/s12028-011-9576-x
bibo:pmid	21748506
has license	no-cc
sha1sum (hex)	a93aae9a7b1add4db17ea73d61a28bb4c7f5d33c
schema:url	https://doi.org/10.1007/s12028-011-9576-x
resource representing a document's title	Obesity is Associated with Reduced Brain Tissue Oxygen Tension After Severe Brain Injury
has PubMed Central identifier	PMC7101992
has PubMed identifier	21748506
schema:publication	Neurocrit Care
resource representing a document's body	covid:a93aae9a7b1add4db17ea73d61a28bb4c7f5d33c#body_text
is schema:about of	named entity 'dependent' named entity 'hypothesis' named entity 'weight' named entity 'Brain Injury' named entity 'CENTER' named entity 'METHODS' named entity 'OXYGEN TENSION' named entity 'mechanical ventilation' named entity 'multivariable analysis' named entity 'Institutional Review Board' named entity 'CVP' named entity 'obese' named entity 'venous return' named entity 'fever' named entity 'brain parenchyma' named entity 'selection bias' named entity 'TBI' named entity 'Acute respiratory distress syndrome' named entity 'ALI' named entity 'biologically active' named entity 'perfusion' named entity 'tested' named entity 'pneumonia' named entity 'interferon gamma' named entity 'sample size' named entity 'tumor necrosis factor alpha' named entity 'obese' named entity 'mmHg' named entity 'resuscitation' named entity 'cardiovascular' named entity 'obesity' named entity 'H1N1' named entity 'risk factor' named entity 'chest trauma' named entity 'obesity' named entity 'obesity' named entity 'acute lung injury' named entity 'Obesity' named entity 'mmHg' named entity 'risk factor' named entity 'arterial pressure' named entity 'multivariable analysis' named entity 'central venous' named entity 'Glasgow Coma Scale' named entity 'ARDS' named entity 'pulmonary function' named entity 'ventilator' named entity 'hemoglobin' named entity 'physiological' named entity 'obese' named entity 'severe' named entity 'reduced' named entity 'brain injury' named entity 'oxygen delivery' named entity 'severe brain injury' named entity 'mass' named entity 'brain tissue' named entity 'Plainsboro' named entity 'Obesity' named entity 'obesity' named entity 'central venous pressure' named entity 'BMI' named entity 'TBI' named entity 'craniotomy' named entity 'adiponectin' named entity 'univariate analysis' named entity 'SAH' named entity 'oxygen delivery' named entity 'Neurointensive Care Unit' named entity 'fraction of inspired oxygen' named entity 'hypoxia' named entity 'cerebral blood flow'

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