About: Structural and functional characterisation of ferret interleukin-2

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About: Structural and functional characterisation of ferret interleukin-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural and functional characterisation of ferret interleukin-2
Creator	Barr, Ian Layton, Daniel Borg, Kathryn Chen, Zhenjun Newman, Janet Pham, Tam Ren, Bin Adams, Timothy Bean, Andrew Laurie, Karen Mckinstry, William
Source	Elsevier; Medline; PMC
abstract	Abstract While the ferret is a valuable animal model for a number of human viral infections, such as influenza, Hendra and Nipah, evaluating the cellular immune response following infection has been hampered by the lack of a number of species-specific immunological reagents. Interleukin 2 (IL-2) is one such key cytokine. Ferret recombinant IL-2 incorporating a C-terminal histidine tag was expressed and purified and the three-dimensional structure solved and refined at 1.89 Å by X-ray crystallography, which represents the highest resolution and first non-human IL-2 structure. While ferret IL-2 displays the classic cytokine fold of the four-helix bundle structure, conformational flexibility was observed at the second helix and its neighbouring region in the bundle, which may result in the disruption of the spatial arrangement of residues involved in receptor binding interactions, implicating subtle differences between ferret and human IL-2 when initiating biological functions. Ferret recombinant IL-2 stimulated the proliferation of ferret lymph node cells and induced the expression of mRNA for IFN-γ and Granzyme A.
has issue date	2016-02-29(xsd:dateTime)
bibo:doi	10.1016/j.dci.2015.10.007
bibo:pmid	26472619
has license	els-covid
sha1sum (hex)	a8b1775df8aeb8d58ddc9df85dd8d268af0d6a0d
schema:url	https://doi.org/10.1016/j.dci.2015.10.007
resource representing a document's title	Structural and functional characterisation of ferret interleukin-2
has PubMed Central identifier	PMC7102629
has PubMed identifier	26472619
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:a8b1775df8aeb8d58ddc9df85dd8d268af0d6a0d#body_text
is schema:about of	named entity 'Ferret' named entity 'evaluating' named entity 'Nipah' named entity 'X-RAY CRYSTALLOGRAPHY' named entity 'MRNA' named entity 'NUMBER OF' named entity 'ITS' named entity 'BUNDLE' named entity 'HELIX' named entity 'CELLS' named entity 'HUMAN' named entity 'INTERACTIONS' named entity 'REAGENTS' named entity 'INFLUENZA' named entity 'EXPRESSED' named entity 'REGION' named entity 'KEY' named entity 'FOLD' named entity 'IFN-G' named entity 'PROLIFERATION' named entity 'SPATIAL' named entity 'NON-' named entity 'RECEPTOR BINDING' named entity 'INVOLVED' named entity 'CONFORMATIONAL FLEXIBILITY' named entity 'CLASSIC' named entity 'DISPLAYS' named entity 'HIGHEST' named entity 'IL-2' named entity 'SECOND' named entity 'SPECIES' named entity 'LYMPH NODE' named entity 'STIMULATED' named entity 'ARRANGEMENT' named entity 'INDUCED' named entity 'GRANZYME A' named entity 'STRUCTURE' named entity 'RECOMBINANT' named entity 'CELLULAR IMMUNE RESPONSE' named entity 'FOLLOWING' named entity 'INFECTION' named entity 'FUNCTIONAL' named entity 'FERRET' named entity 'VIRAL INFECTIONS' named entity 'INITIATING' named entity 'FERRET' named entity 'THREE-DIMENSIONAL' named entity 'LACK' named entity 'INTERLEUKIN-2' named entity 'RESOLUTION' named entity 'OBSERVED' named entity 'C-TERMINAL' named entity 'CYTOKINE' named entity 'HISTIDINE TAG' named entity 'STRUCTURAL' named entity 'RESULT' named entity 'EVALUATING' named entity 'IMMUNOLOGICAL' named entity 'SPECIFIC' named entity 'ANIMAL MODEL' named entity 'INTERLEUKIN 2' named entity 'IS A' named entity 'DISRUPTION' named entity 'PURIFIED' named entity 'EXPRESSION' named entity 'BIOLOGICAL FUNCTIONS' covid:arg/a8b1775df8aeb8d58ddc9df85dd8d268af0d6a0d named entity 'subtle' named entity 'While' named entity 'structure' named entity 'four-helix bundle'

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