About: Immune response of mature cows subjected to annual booster vaccination against neonatal calf diarrhoea with two different commercial vaccines: A non-inferiority study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune response of mature cows subjected to annual booster vaccination against neonatal calf diarrhoea with two different commercial vaccines: A non-inferiority study
Creator	Bainbridge, Tracy Bennemann, Johanna Dressel, Klaus-Ulrich Durel, Luc Maillard, Renaud Rose, Clancy Roubert, Julien Rückner, Antje Vahlenkamp, Thomas
Source	Elsevier; Medline; PMC
abstract	Abstract Neonatal calf diarrhoea can have important economic consequences. Scour vaccines are available against some of the most frequent pathogens responsible for this disease: Bovine Rotavirus (BoRV), Bovine Coronavirus (BoCV) and E. coli K99. In this multi-centre, randomised, blinded study, adult cows vaccinated with a trivalent vaccine marketed for years (Rotavec™ Corona, MSD Animal Health - RC) prior to last parturition were revaccinated 12–15 months later, prior to the upcoming parturition, with either a single injection of a recently marketed vaccine (Bovigen™ Scour, Virbac - BS), or RC. The aim of this trial was to verify whether BS is not inferior to RC for the stimulation of the immune response and the passive transfer to calves in these conditions. A total of 136 multiparous dairy cows, from 5 different herds and located in 3 countries (France, UK and Germany) were enrolled in the study. Sixty-five cows were vaccinated with BS and 71 with RC. Antibody levels, measured by competitive ELISA and represented as percentage of inhibition (PI), were assessed in the cow's serum (on the day of vaccination: D0 and on days 21, 42 and at calving), in the colostrum and in the serum of calves in the first week of life. Differences in means of PI between groups and the 95% confidence interval (CI) were calculated. The non-inferiority threshold was set at −10%. The relationships between antibody levels in the colostrum and the vaccination-calving interval (VCI) or the inter-booster vaccination interval (IBVI) were also analysed. All the lower margins of the 95% CI of the difference in means of PI, in all samples and for the 3 pathogens assessed, were above −10%. This result shows that BS is not inferior to RC for the stimulation of the immune response against BoRV, BoCV and E. coli K99 and the passive transfer of immunity to calves when this vaccine is administered to their dams previously vaccinated with RC. Furthermore, no correlation was found between PI values in the colostrum and the VCI or IBVI. The ratio of animals with a PI ≥ 95% in the colostrum, among cows with similar intervals, was not significantly different between groups, for all antigens tested. Therefore, this study shows that a single injection of the heterologous vaccine BS can be used as a booster in cattle previously vaccinated with RC.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1016/j.livsci.2017.08.011
bibo:pmid	32288873
has license	els-covid
sha1sum (hex)	a8893c285a00dd167b0c70f3aea0103a2ef2e6b5
schema:url	https://doi.org/10.1016/j.livsci.2017.08.011
resource representing a document's title	Immune response of mature cows subjected to annual booster vaccination against neonatal calf diarrhoea with two different commercial vaccines: A non-inferiority study
has PubMed Central identifier	PMC7102762
has PubMed identifier	32288873
schema:publication	Livestock Science
resource representing a document's body	covid:a8893c285a00dd167b0c70f3aea0103a2ef2e6b5#body_text
is schema:about of	named entity 'DIFFERENT' named entity 'levels' named entity 'booster' named entity 'annual' named entity 'neonatal' named entity 'VACCINATION INTERVAL' named entity 'IMMUNE RESPONSE' named entity 'MEASURED' named entity 'DAYS' named entity 'MEANS' named entity 'INHIBITION' named entity 'ANIMAL HEALTH' named entity 'CALCULATED' named entity 'COMPETITIVE ELISA' named entity 'STIMULATION' named entity 'ASSESSED' named entity 'RELATIONSHIPS' named entity 'THESE' named entity 'COUNTRIES' named entity 'AIM' named entity 'COLOSTRUM' named entity 'VACCINE' named entity 'NEONATAL CALF DIARRHOEA' named entity 'IMMUNE RESPONSE' named entity 'COMMERCIAL' named entity '136' named entity 'PARTURITION' named entity 'MONTHS' named entity 'CALVING' named entity 'YEARS' named entity 'DIFFERENT' named entity 'PASSIVE' named entity 'COWS' named entity 'DAY' named entity 'STUDY' named entity 'ANNUAL' named entity 'BOOSTER VACCINATION' named entity 'MATURE' named entity '9210' named entity '27S' named entity 'THRESHOLD' named entity 'CENTRE' named entity 'NON-INFERIORITY' named entity 'CONFIDENCE INTERVAL' named entity 'VERIFY' named entity 'BLINDED STUDY' named entity 'INJECTION' named entity 'VACCINATION' named entity 'NON-INFERIORITY' named entity 'VACCINES' named entity 'COWS' named entity 'SIXTY-FIVE' named entity 'MULTIPAROUS' named entity 'TRANSFER' named entity 'SINGLE' named entity 'LIFE' named entity 'SERUM' named entity 'TRIAL' named entity 'ADULT' named entity 'VACCINATED' named entity 'TOTAL' named entity 'INFERIOR' named entity 'EITHER' named entity 'STUDY' named entity 'WEEK' named entity 'GERMANY' named entity 'LOCATED IN' named entity 'RECENTLY' named entity 'INTER-' named entity 'COW' named entity 'CALVES' named entity 'LATER' named entity 'ANTIBODY'

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