About: Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression

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About: Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression
Creator	Schwanke, Hella Brinkmann, Melanie Stempel, Markus
Source	PMC
abstract	The type I interferon (IFN) response is a principal component of our immune system that allows to counter a viral attack immediately upon viral entry into host cells. Upon engagement of aberrantly localised nucleic acids, germline-encoded pattern recognition receptors convey their find via a signalling cascade to prompt kinase-mediated activation of a specific set of five transcription factors. Within the nucleus, the coordinated interaction of these dimeric transcription factors with coactivators and the basal RNA transcription machinery is required to access the gene encoding the type I IFN IFNβ (IFNB1). Virus-induced release of IFNβ then induces the antiviral state of the system and mediates further mechanisms for defence. Due to its key role during the induction of the initial IFN response, the activity of the transcription factor interferon regulatory factor 3 (IRF3) is tightly regulated by the host and fiercely targeted by viral proteins at all conceivable levels. In this review, we will revisit the steps enabling the trans-activating potential of IRF3 after its activation and the subsequent assembly of the multi-protein complex at the IFNβ enhancer that controls gene expression. Further, we will inspect the regulatory mechanisms of these steps imposed by the host cell and present the manifold strategies viruses have evolved to intervene with IFNβ transcription downstream of IRF3 activation in order to secure establishment of a productive infection.
has issue date	2020-07-07(xsd:dateTime)
bibo:doi	10.3390/v12070733
bibo:pmid	32645843
has license	cc-by
sha1sum (hex)	a88229c823a05bcae7b40f6e3bce55b0b411d65e
schema:url	https://doi.org/10.3390/v12070733
resource representing a document's title	Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression
has PubMed Central identifier	PMC7411613
has PubMed identifier	32645843
schema:publication	Viruses
resource representing a document's body	covid:a88229c823a05bcae7b40f6e3bce55b0b411d65e#body_text
is schema:about of	named entity 'coactivators' named entity 'activation' named entity 'induces' named entity 'potential' named entity 'IFN' named entity 'signalling cascade' named entity 'IRF3' named entity 'cell' named entity 'set' named entity 'subsequent' named entity 'evolved' named entity 'host' named entity 'transcription factors' named entity 'steps' named entity 'levels' named entity 'enhancer' named entity 'gene expression' named entity 'coactivators' named entity 'RNA transcription' named entity 'viral entry' named entity 'gene' named entity 'transcription factor' named entity 'viruses' named entity 'Virus' named entity 'IRF3' named entity 'IFNB1' named entity 'Viral' named entity 'principal component' named entity 'IFN' named entity 'attack' named entity 'isoform' named entity 'initiation complex' named entity 'protein-protein interactions' named entity 'IRF3' named entity 'signal transduction' named entity 'E3 ubiquitin ligase' named entity 'IRF3' named entity 'IRF3' named entity 'interact' named entity 'dimerisation' named entity 'AdV' named entity 'proteins expressed' named entity 'murine' named entity 'phosphate group' named entity 'CBP/p300' named entity 'CBP' named entity 'IFNB1' named entity 'E3C' named entity 'IRF3' named entity 'biological activity' named entity 'chromatin immunoprecipitation' named entity 'ISG15' named entity 'transcription factor' named entity 'enhancer' named entity 'type I IFN' named entity 'coactivator' named entity 'dimerisation' named entity 'IκB kinase' named entity 'IRF3' named entity 'DNA binding' named entity 'LANA-1' named entity 'IRF3' named entity 'phosphorylated' named entity 'negative regulation' named entity 'IRF3' named entity 'long non-coding RNA' named entity 'IRF3' named entity 'IRF3' named entity 'coactivators' named entity 'IRF3' named entity 'moiety' named entity 'type II IFN' named entity 'IRF3' named entity 'living cells' named entity 'IRF3' named entity 'IFNAR' named entity 'IRF3' named entity 'positive feedback' named entity 'p300'

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