About: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
Creator	Wang, Ke Xu, Shuyun Zhou, Min Zhang, Cong Zhao, Jianping Li, Xiaochen Zhang, Yang Shi, Jing Zhou, Ying Renz, Harald Xie, Jungang Tao, Yu Wu, Bo Xie, J Liu, ; Md, Wang Phd, Zhang Xie, Liu Xie, Min Yu, Muqing Zhang, Zhiguo Yue, Junqing Cong, ; Ke, ; Liu, Xiansheng Md, Yu Md, Zhang Muqing, ; Yang, Zhenyu Zhiguo, ;
Source	Elsevier; Medline; PMC
abstract	Abstract Background In December 2019, COVID-19 outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. Objective The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. Methods Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020 to February 5, 2020 were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. Results We identified 269 (49.1%) of 548 patients as severe cases on admission. Elder age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-a), and high LDH level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in COVID-19 patients was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male, elder age, leukocytosis, high LDH level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19. Conclusions Patients with elder age, hypertension, and high LDH level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have high risk of death.
has issue date	2020-04-12(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2020.04.006
bibo:pmid	32294485
has license	els-covid
sha1sum (hex)	a87913336d15af51143dda9b56b9cebe5a95a871
schema:url	https://doi.org/10.1016/j.jaci.2020.04.006
resource representing a document's title	Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
has PubMed Central identifier	PMC7152876
has PubMed identifier	32294485
schema:publication	J Allergy Clin Immunol
resource representing a document's body	covid:a87913336d15af51143dda9b56b9cebe5a95a871#body_text
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