About: Ketamine as an Anesthetic for Patients with Acute Brain Injury: A Systematic Review

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ketamine as an Anesthetic for Patients with Acute Brain Injury: A Systematic Review
Creator	Christian, Mads Craveiro Brøchner, Anne Gregers, Tofte Lindvig, Katrine Mikkelsen, Søren
Source	Medline; PMC
abstract	For years, the use of ketamine as an anesthetic to patients suffering from acute brain injury has been debated because of its possible deleterious effects on the cerebral circulation and thus on the cerebral perfusion. Early studies suggested that ketamine could increase the intracranial pressure thus lowering the cerebral perfusion and hence reduce the oxygen supply to the injured brain. However, more recent studies are less conclusive and might even indicate that patients with acute brain injury could benefit from ketamine sedation. This systematic review summarizes the evidence regarding the use of ketamine in patients suffering from traumatic brain injury. Databases were searched for studies using ketamine in acute brain injury. Outcomes of interest were mortality, intracranial pressure, cerebral perfusion pressure, blood pressure, heart rate, spreading depolarizations, and neurological function. In total 11 studies were included. The overall level of evidence concerning the use of ketamine in brain injury is low. Only two studies found a small increase in intracranial pressure, while two small studies found decreased levels of intracranial pressure following ketamine administration. We found no evidence of harm during ketamine use in patients suffering from acute brain injury.
has issue date	2020-04-23(xsd:dateTime)
bibo:doi	10.1007/s12028-020-00975-7
bibo:pmid	32328972
has license	cc-by
sha1sum (hex)	a8779a1110ef275570b74b8f0719e05af5713eb6
schema:url	https://doi.org/10.1007/s12028-020-00975-7
resource representing a document's title	Ketamine as an Anesthetic for Patients with Acute Brain Injury: A Systematic Review
has PubMed Central identifier	PMC7223585
has PubMed identifier	32328972
schema:publication	Neurocrit Care
resource representing a document's body	covid:a8779a1110ef275570b74b8f0719e05af5713eb6#body_text
is schema:about of	named entity 'cerebral perfusion pressure' named entity 'ketamine' named entity 'studies' named entity 'Anesthetic' named entity 'DECREASED' named entity 'TOTAL' named entity 'OVERALL' named entity 'RECENT' named entity 'INCLUDED' named entity 'SMALL' named entity 'POSSIBLE' named entity 'LOWERING' named entity 'USE OF' named entity 'INJURED' named entity 'ITS' named entity 'SEDATION' named entity 'acute' named entity 'ketamine' named entity 'acute' named entity 'brain injury' named entity 'summarizes' named entity 'mortality' named entity 'studies' named entity 'spreading depolarizations' named entity 'suffering' named entity 'patients' named entity 'brain' named entity 'Brain Injury' named entity 'neurological function' named entity 'brain injury' named entity 'oxygen supply' named entity 'cerebral perfusion pressure' named entity 'ketamine' named entity 'ketamine' named entity 'brain injury' named entity 'ketamine' named entity 'intracranial pressure' named entity 'intracranial pressure' named entity 'traumatic brain injury' named entity 'sedation' named entity 'anesthetic' named entity 'intracranial pressure' named entity 'ketamine' named entity 'total' named entity 'anesthetic' named entity 'mmHg' named entity 'ketamine' named entity 'lack of energy' named entity 'ketamine' named entity 'ischemic' named entity 'hemodynamics' named entity 'ketamine' named entity 'ischemia' named entity 'animal studies' named entity 'ketamine' named entity 'general anesthetic' named entity 'vascular bed' named entity 'ketamine' named entity 'CPP' named entity 'neurological' named entity 'systolic blood pressure' named entity 'anesthetic agents' named entity 'ketamine' named entity 'ketamine' named entity 'attrition bias' named entity 'TBI' named entity 'cardiac surgery' named entity 'ketamine' named entity 'brain injuries' named entity 'biomarkers' named entity 'brain injury' named entity 'mechanical ventilator' named entity 'long-term' named entity 'intracranial pressure' named entity 'ketamine' named entity 'ischemia' named entity 'ketamine'

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