About: Timing COVID-19 - Synchronization of longitudinal patient data to the underlying disease progression using CRP as a temporal marker

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About: Timing COVID-19 - Synchronization of longitudinal patient data to the underlying disease progression using CRP as a temporal marker Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Timing COVID-19 - Synchronization of longitudinal patient data to the underlying disease progression using CRP as a temporal marker
Creator	Garcia, Pedro Brugger, Silvio Hilty, Matthias Krauthammer, Michael Schuepbach, Reto Allam, Ahmed Bartussek, Jan Buehler, Philipp Ganter, Christoph Maibach, Martina Perez Gonzalez, Nicolas
Source	MedRxiv
abstract	Advances in medical technology and IT infrastructure have led to increased availability of continuous patient data that allows to investigate the longitudinal progression of novel and known diseases in unprecedented detail. However, to accurately describe any underlying pathophysiology with longitudinal data, the individual patient trajectories have to be synchronized based on temporal markers. In this study, we use longitudinal data from 28 critically ill ICU COVID-19 patients to compare the commonly used alignment markers %22onset of symptoms%22, %22hospital admission%22 and %22ICU admission%22 with a novel objective method based on the peak value of inflammatory marker C-reactive protein (CRP). By applying our CRP-based method to align the progression of neutrophils and lymphocytes, we were able to define a pathophysiological window that allowed further mortality risk stratification in our COVID-19 patient cohort. Our data highlights that proper synchronization of patient data to the underlying pathophysiology is crucial to differentiate severity subgroups and to allow reliable interpatient comparisons.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1101/2020.06.11.20128041
has license	medrxiv
sha1sum (hex)	a87020e2b4a7e4f16805ea322ae784ad0c49e76c
schema:url	https://doi.org/10.1101/2020.06.11.20128041
resource representing a document's title	Timing COVID-19 - Synchronization of longitudinal patient data to the underlying disease progression using CRP as a temporal marker
resource representing a document's body	covid:a87020e2b4a7e4f16805ea322ae784ad0c49e76c#body_text
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