About: Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors
Creator	Wang, Jing Li, A Liu, Jue Jiang, Taozhen Ae, Shi Ae, Wei Lei, A
Source	Medline; PMC
abstract	Infectious bursal disease virus (IBDV) is the etiological agent of a highly contagious disease in chickens. In a recent report, proteasome inhibitor MG132 has been shown to completely inhibit IBDV-induced apoptosis. This raises the possibility that the ubiquitin–proteasome pathway may be used by the virus to promote viral replication. In this study, we examined the interplay between IBDV replication and the ubiquitin–proteasome pathway in cultured cells. Treatment of DF-1 cells with the proteasome inhibitors MG132 or lactacystin significantly decreased virus release in the supernatant and prevented virus-induced cytopathic effect. Inhibition of the ubiquitin–proteasome pathway did reduce markedly viral RNA transcription and protein translation but not affect virus internalization. We also demonstrated that IBDV activates caspase pathway via triggering the efflux of cytochrome c in mitochondria into cytosol of infected cells. This activity was dose-dependently reduced by proteasome inhibitor treatment. Taken together, our data suggest that proteasome inhibitor reduces IBDV replication through inhibition of viral RNA transcription and protein synthesis, and thus preventing IBDV-induced apoptosis.
has issue date	2007-08-07(xsd:dateTime)
bibo:doi	10.1007/s11262-007-0147-3
bibo:pmid	17680216
has license	no-cc
sha1sum (hex)	a84164ed45871caa8e9320d0a464ed6351c485dc
schema:url	https://doi.org/10.1007/s11262-007-0147-3
resource representing a document's title	Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors
has PubMed Central identifier	PMC7089216
has PubMed identifier	17680216
schema:publication	Virus Genes
resource representing a document's body	covid:a84164ed45871caa8e9320d0a464ed6351c485dc#body_text
is schema:about of	named entity 'affect' named entity 'preventing' named entity 'apoptosis' named entity 'mitochondria' named entity 'demonstrated' named entity 'contagious disease' named entity 'PROTEASOME INHIBITORS' named entity 'DID' named entity 'PROTEIN SYNTHESIS' named entity 'MAY BE' named entity 'INFECTED' named entity 'VIRUS' named entity 'AGENT' named entity 'REDUCED' named entity 'OUR' named entity 'EXAMINED' named entity 'USED BY' named entity 'CYTOCHROME C' named entity 'MARKEDLY' named entity 'DECREASED' named entity 'PROMOTE' covid:arg/a84164ed45871caa8e9320d0a464ed6351c485dc named entity 'STUDY' named entity 'BUT' named entity 'INHIBITOR TREATMENT' named entity 'REDUCE' named entity 'DOSE' named entity 'APOPTOSIS' named entity 'SUGGEST' named entity 'UBIQUITIN-PROTEASOME PATHWAY' named entity 'VIRUS RELEASE' named entity 'CELLS' named entity 'TRIGGERING' named entity 'EFFLUX' named entity 'RECENT' named entity 'CHICKENS' named entity 'REPLICATION' named entity 'CULTURED CELLS' named entity 'VIRUS INTERNALIZATION' named entity 'DATA' named entity 'DEMONSTRATED' named entity 'AFFECT' named entity 'VIRAL REPLICATION' named entity 'CASPASE PATHWAY' named entity 'PROTEASOME INHIBITOR' named entity 'INFECTIOUS BURSAL DISEASE VIRUS' named entity 'MITOCHONDRIA' named entity 'VIRAL RNA' named entity 'HIGHLY CONTAGIOUS DISEASE' named entity 'ACTIVITY' named entity 'LACTACYSTIN' named entity 'PREVENTING' named entity 'CYTOPATHIC EFFECT' named entity 'INDUCED' named entity 'COMPLETELY' named entity 'INFECTIOUS BURSAL DISEASE VIRUS' named entity 'VIRUS REPLICATION' named entity 'REDUCTION' named entity 'PROTEASOME INHIBITORS' named entity 'CYTOSOL' named entity 'POSSIBILITY' named entity 'REPORT' named entity 'IBDV' named entity 'DF-1' named entity 'TRANSCRIPTION' named entity 'CULTURED CELLS' named entity 'PROTEIN TRANSLATION' named entity 'SUPERNATANT' named entity 'INHIBITION' named entity 'ACTIVATES' named entity 'TAKEN' named entity 'TREATMENT' named entity 'lactacystin' named entity 'ubiquitin-proteasome pathway' named entity 'protein synthesis'

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