About: Risk of COVID-19 in health-care workers in Denmark: an observational cohort study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Risk of COVID-19 in health-care workers in Denmark: an observational cohort study
Creator	Andersen, Ove Ditlev, Sisse Fischer, Thea Benfield, Thomas Antonio, Claus Bundgaard, Henning Christensen, Casper Dam Nielsen, Susanne Fogh, Kamille Folke, Fredrik Gybel-Brask, Mikkel Hageman, Ida Harritshøj, Lene Hasselbalch, Rasmus Hother, Christoffer Iversen, Kasper Jensen, Juul Knudsen, Andreas Kristensen, Jonas Larsen, Margit Møgelvang, Rasmus Nielsen, Pernille Norsk, Jakob Pries-Heje, Mia Rungby, Jørgen Sten, Curt Sørensen, Erik Torp-Pedersen, Christian Ullum, Henrik
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Health-care workers are thought to be highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the prevalence of antibodies against SARS-CoV-2 in health-care workers and the proportion of seroconverted health-care workers with previous symptoms of COVID-19. METHODS: In this observational cohort study, screening was offered to health-care workers in the Capital Region of Denmark, including medical, nursing, and other students who were associated with hospitals in the region. Screening included point-of-care tests for IgM and IgG antibodies against SARS-CoV-2. Test results and participant characteristics were recorded. Results were compared with findings in blood donors in the Capital Region in the study period. FINDINGS: Between April 15 and April 23, 2020, we screened 29 295 health-care workers, of whom 28 792 (98·28%) provided their test results. We identified 1163 (4·04% [95% CI 3·82–4·27]) seropositive health-care workers. Seroprevalence was higher in health-care workers than in blood donors (142 [3·04%] of 4672; risk ratio [RR] 1·33 [95% CI 1·12–1·58]; p<0·001). Seroprevalence was higher in male health-care workers (331 [5·45%] of 6077) than in female health-care workers (832 [3·66%] of 22 715; RR 1·49 [1·31–1·68]; p<0·001). Frontline health-care workers working in hospitals had a significantly higher seroprevalence (779 [4·55%] of 16 356) than health-care workers in other settings (384 [3·29%] of 11 657; RR 1·38 [1·22–1·56]; p<0·001). Health-care workers working on dedicated COVID-19 wards (95 [7·19%] of 1321) had a significantly higher seroprevalence than other frontline health-care workers working in hospitals (696 [4·35%] of 15 983; RR 1·65 [1·34–2·03]; p<0·001). 622 [53·5%] of 1163 seropositive participants reported symptoms attributable to SARS-CoV-2. Loss of taste or smell was the symptom that was most strongly associated with seropositivity (377 [32·39%] of 1164 participants with this symptom were seropositive vs 786 [2·84%] of 27 628 without this symptom; RR 11·38 [10·22–12·68]). The study is registered at ClinicalTrials.gov, NCT04356560. INTERPRETATION: The prevalence of health-care workers with antibodies against SARS-CoV-2 was low but higher than in blood donors. The risk of SARS-CoV-2 infection in health-care workers was related to exposure to infected patients. More than half of seropositive health-care workers reported symptoms attributable to COVID-19. FUNDING: Lundbeck Foundation.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.1016/s1473-3099(20)30589-2
bibo:pmid	32758438
has license	no-cc
sha1sum (hex)	a831b8d089ccaa7c841502b89353ddc8fcef8fb8
schema:url	https://doi.org/10.1016/s1473-3099%2820%2930589-2
resource representing a document's title	Risk of COVID-19 in health-care workers in Denmark: an observational cohort study
has PubMed Central identifier	PMC7398038
has PubMed identifier	32758438
schema:publication	Lancet Infect Dis
resource representing a document's body	covid:a831b8d089ccaa7c841502b89353ddc8fcef8fb8#body_text
is schema:about of	named entity 'prevalence' named entity 'workers' named entity 'BACKGROUND' named entity 'INFECTION' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'infection' named entity 'Denmark' named entity 'health-care' named entity 'seropositivity' named entity 'health-care' named entity 'IgG' named entity 'critical illness' named entity 'Blood donors' named entity 'health-care' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'health-care' named entity 'health-care' named entity 'antibody' named entity 'PCR' named entity 'Novo Nordisk Foundation' named entity 'Novo Nordisk' named entity 'study population' named entity 'doctors, nurses' named entity 'cohort study' named entity 'seroprevalence' named entity 'COVID' named entity 'COVID' named entity 'COVID-19' named entity 'seropositivity' named entity 'health-care' named entity 'COVID' named entity 'Denmark' named entity 'symptom' named entity 'pharyngeal' named entity 'blood bank' named entity '95% CI' named entity 'general population' named entity 'doctors, nurses' named entity 'immunological response' named entity 'GSK' named entity 'JBN' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'seropositivity' named entity 'seroconversion' named entity 'COVID' named entity 'tested positive for COVID-19' named entity 'point-of-care test' named entity 'SARS-CoV-2' named entity 'IgG' named entity 'PCR-based' named entity 'IgM'

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