About: Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study

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About: Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study
Creator	Guan, Y Ng, W Chan, C Yuen, K Chu, C Chan, K Peiris, J Poon, L Chan, H Cheng, C Kong, Hong Mrcp, Hung Yuen, Y Zheng, J Dphil, Peiris Frcp, Hon Frcpa, Lai Hon, Y Hospital, Christian Hung, F Lai, R Law, K Mrcp, Chu Mrcp, Ng Ng, J Tang, B S F
Source	Elsevier; Medline; PMC
abstract	Summary Background We investigated the temporal progression of the clinical, radiological, and virological changes in a community outbreak of severe acute respiratory syndrome (SARS). Methods We followed up 75 patients for 3 weeks managed with a standard treatment protocol of ribavirin and corticosteroids, and assessed the pattern of clinical disease, viral load, risk factors for poor clinical outcome, and the usefulness of virological diagnostic methods. Findings Fever and pneumonia initially improved but 64 (85%) patients developed recurrent fever after a mean of 8.9 (SD 3.1) days, 55 (73%) had watery diarrhoea after 7.5 (2.3) days, 60 (80%) had radiological worsening after 7.4 (2.2) days, and respiratory symptoms worsened in 34 (45%) after 8.6 (3.0) days. In 34 (45%) patients, improvement of initial pulmonary lesions was associated with appearance of new radiological lesions at other sites. Nine (12%) patients developed spontaneous pneumomediastinum and 15 (20%) developed acute respiratory distress syndrome (ARDS) in week 3. Quantitative reverse-transcriptase (RT) PCR of nasopharyngeal aspirates in 14 patients (four with ARDS) showed peak viral load at day 10, and at day 15 a load lower than at admission. Age and chronic hepatitis B virus infection treated with lamivudine were independent significant risk factors for progression to ARDS (p=0.001). SARS-associated coronavirus in faeces was seen on RT-PCR in 65 (97%) of 67 patients at day 14. The mean time to seroconversion was 20 days. Interpretation The consistent clinical progression, shifting radiological infiltrates, and an inverted V viral-load profile suggest that worsening in week 2 is unrelated to uncontrolled viral replication but may be related to immunopathological damage. Published online May 9, 2003 http://image.thelancet.com/extras/03art4432web.pdf
has issue date	2003-05-24(xsd:dateTime)
bibo:doi	10.1016/s0140-6736(03)13412-5
bibo:pmid	12781535
has license	els-covid
sha1sum (hex)	a80c3e9dfde9824cb8f54f9f382d0d601743ffc0
schema:url	https://doi.org/10.1016/s0140-6736%2803%2913412-5
resource representing a document's title	Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study
has PubMed Central identifier	PMC7112410
has PubMed identifier	12781535
schema:publication	The Lancet
resource representing a document's body	covid:a80c3e9dfde9824cb8f54f9f382d0d601743ffc0#body_text
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