About: Interactions of Alphavirus nsP3 Protein with Host Proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interactions of Alphavirus nsP3 Protein with Host Proteins
Creator	Taylor, Adam Narayanan, Aarthi Keck, Forrest Lark, Tyler Coombs, Kevin Lal, Sunil
Source	Medline; PMC
abstract	Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus infections can lead to encephalitic outcomes in the infected host. Of the non-structural proteins (nsPs) that the viruses code for, nsP3 is the least understood in terms of function. Alphavirus nsP3s are characterized by regions with significantly conserved domain structure along with regions of high variability. Interactions of nsP3 with several host proteins have been documented including, stress granule-related proteins, dead box proteins, heat shock proteins, and kinases. In some cases, in addition to the interaction, requirement of the interaction to support infection has been demonstrated. An understanding of the proteomic network of nsP3 and the mechanisms by which these interactions support the establishment of a productive infection would make alphavirus nsP3 an interesting target for design of effective medical countermeasures.
has issue date	2018-01-09(xsd:dateTime)
bibo:doi	10.3389/fmicb.2017.02652
bibo:pmid	29375517
has license	cc-by
sha1sum (hex)	a79847f406c9f694222cc18a1ffd04dbc0c06d08
schema:url	https://doi.org/10.3389/fmicb.2017.02652
resource representing a document's title	Interactions of Alphavirus nsP3 Protein with Host Proteins
has PubMed Central identifier	PMC5767282
has PubMed identifier	29375517
schema:publication	Front Microbiol
resource representing a document's body	covid:a79847f406c9f694222cc18a1ffd04dbc0c06d08#body_text
is schema:about of	named entity 'INTERACTIONS' named entity 'PROTEINS' named entity 'heat shock proteins' named entity 'dead box' named entity 'proteins' named entity 'stress' named entity 'Alphavirus' named entity 'proteomic' named entity 'PROTEINS' named entity 'CHARACTERIZED' named entity 'INTERESTING' named entity 'PRODUCTIVE' named entity 'STRESS GRANULE' named entity 'REQUIREMENT' named entity 'HOST' named entity 'SUPPORT' named entity 'UNDERSTANDING' named entity 'TOGAVIRIDAE' named entity 'UNDERSTOOD' named entity 'MAKE' named entity 'INTERACTIONS' named entity 'NON-STRUCTURAL PROTEINS' named entity 'DOMAIN STRUCTURE' named entity 'ALPHAVIRUSES' named entity 'ALPHAVIRUS' named entity 'HAVE' named entity 'ESTABLISHMENT' named entity 'CATEGORIES' named entity 'FUNCTION' named entity 'KINASES' named entity 'INFECTION' named entity 'NSP3' named entity 'MEMBERS' named entity 'DEAD' named entity 'INTERACTION' named entity 'DESIGN' named entity 'OUTCOMES' named entity 'ASSOCIATED WITH' named entity 'DEMONSTRATED' named entity 'EFFECTIVE' named entity 'HOST' named entity 'PROTEIN ' named entity 'NETWORK' named entity 'ALPHAVIRUS INFECTIONS' named entity 'INCLUDING' named entity 'FAMILY' named entity 'CONSERVED' named entity 'TERMS' named entity 'HEAT SHOCK PROTEINS' named entity 'MECHANISMS' named entity 'ADDITION' named entity 'GROUPED' named entity 'HIGH VARIABILITY' named entity 'BOX' named entity 'DOCUMENTED' named entity 'VIRUSES' named entity 'LEAD' named entity 'ALPHAVIRUS' named entity 'INFECTED HOST' named entity 'CASES' named entity 'NSP3' named entity 'TARGET' named entity 'REGIONS' named entity 'MEDICAL COUNTERMEASURES' named entity 'RELATED' named entity 'PROTEOMIC' named entity 'TO SUPPORT' named entity 'CODE' named entity 'THESE' named entity 'target' named entity 'high' named entity 'encephalitic' named entity 'infected' named entity 'arthritic' named entity 'kinases' named entity 'encephalitic'

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