About: Avian Influenza A Virus Infects Swine Airway Epithelial Cells without Prior Adaptation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Avian Influenza A Virus Infects Swine Airway Epithelial Cells without Prior Adaptation
Creator	Herrler, Georg Yang, Wei Peng, Ju-Yi Wu, Nai-Huei Sawatsky, Bevan Von Messling, Veronika Shin, Dai-Lun
source	PMC
abstract	Pigs play an important role in the interspecies transmission of influenza A viruses (IAV). The porcine airway epithelium contains binding sites for both swine/human IAV (α2,6-linked sialic acids) and avian IAV (α2,3-linked sialic acids) and therefore is suited for adaptation of viruses from other species as suggested by the “mixing vessel theory”. Here, we applied well-differentiated swine airway epithelial cells to find out whether efficient infection by avian IAV requires prior adaption. Furthermore, we analyzed the influence of the sialic acid-binding activity and the virus-induced detrimental effects. Surprisingly, an avian IAV H1N1 strain circulating in European poultry and waterfowl shows increased and prolonged viral replication without inducing a strong innate immune response. This virus could infect the lower respiratory tract in our precision cut-lung slice model. Pretreating the cells with poly (I:C) and/or JAK/STAT pathway inhibitors revealed that the interferon-stimulated innate immune response influences the replication of avian IAV in swine airway epitheliums but not that of swine IAV. Further studies indicated that in the infection by IAVs, the binding affinity of sialic acid is not the sole factor affecting the virus infectivity for swine or human airway epithelial cells, whereas it may be crucial in well-differentiated ferret tracheal epithelial cells. Taken together, our results suggest that the role of pigs being the vessel of interspecies transmission should be reconsidered, and the potential of avian H1N1 viruses to infect mammals needs to be characterized in more detail.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.3390/v12060589
bibo:pmid	32481674
has license	cc-by
sha1sum (hex)	a797a4f9bce5f02b62de8ef6acfd89e538d87be7
schema:url	https://doi.org/10.3390/v12060589
resource representing a document's title	Avian Influenza A Virus Infects Swine Airway Epithelial Cells without Prior Adaptation
has PubMed Central identifier	PMC7374723
has PubMed identifier	32481674
schema:publication	Viruses
resource representing a document's body	covid:a797a4f9bce5f02b62de8ef6acfd89e538d87be7#body_text
is schema:about of	named entity 'potential' named entity 'suited' named entity 'swine' named entity 'sialic' covid:arg/a797a4f9bce5f02b62de8ef6acfd89e538d87be7 named entity 'sialic acids' named entity 'prior' named entity 'viruses' named entity 'inhibitors' named entity 'IAV' named entity 'porcine' named entity 'H1N1' named entity 'sialic acids' named entity 'factor' named entity 'linked' named entity 'Epithelial' named entity 'infectivity' named entity 'IAV' named entity 'mammals' named entity 'infection' named entity 'sialic acid' named entity 'viruses' named entity 'virus' named entity 'epithelial cells' named entity 'swine' named entity 'interferon' named entity 'IAV' named entity 'porcine' named entity 'Airway' named entity 'Epithelial Cells' named entity 'murine' named entity 'San Diego' named entity 'PBS' named entity 'epithelium' named entity 'innate immune response' named entity 'MDCK' named entity 'ferret' named entity 'sialic acid' named entity 'trachea' named entity 'Statistical significance' named entity 'apical surface' named entity 'antiviral' named entity 'sialic acid' named entity 'RNA' named entity 'epithelial cells' named entity 'titer' named entity 'JAK/STAT signaling' named entity 'infection' named entity 'Immunofluorescent' named entity 'Weill Cornell Medical College' named entity 'infection' named entity 'cDNA' named entity 'ISGs' named entity 'infection' named entity 'lungs' named entity 'Influenza' named entity 'virus infection' named entity 'β-actin' named entity 'protease' named entity 'immune modulation' named entity 'reverse transcribed' named entity 'titer' named entity 'IAV' named entity 'Mannheim' named entity 'infection' named entity 'pseudostratified' named entity 'counterstain' named entity 'epithelial cells' named entity 'ferret' named entity 'influenza' named entity 'DMEM' named entity 'chicken' named entity 'infection' named entity 'ferret' named entity 'human species'

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