About: MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
Creator	Frieman, Matthew Venkataraman, Thiagarajan Liu, Ye Glenn, Gregory Smith, Gale Coleman, Christopher Flyer, David
Source	Elsevier; Medline; PMC
abstract	The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies in vivo, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection in vivo.
has issue date	2017-03-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2017.02.012
bibo:pmid	28237499
has license	bronze-oa
sha1sum (hex)	a7960070f97e42542f5a3a758e454edffc32ad89
schema:url	https://doi.org/10.1016/j.vaccine.2017.02.012
resource representing a document's title	MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
has PubMed Central identifier	PMC5423355
has PubMed identifier	28237499
schema:publication	Vaccine
resource representing a document's body	covid:a7960070f97e42542f5a3a758e454edffc32ad89#body_text
is schema:about of	named entity 'adjuvant' named entity 'MERS-CoV' named entity 'therapeutics' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'NEUTRALIZING ANTIBODY' named entity '28S' named entity 'CAUSE' covid:arg/a7960070f97e42542f5a3a758e454edffc32ad89 named entity 'IDEAL' named entity 'VACCINE' named entity 'HIGH' named entity 'CELLS' named entity 'THERAPEUTICS' named entity 'PROTEIN ' named entity 'PROTECTION' named entity 'NANOPARTICLE' named entity 'INFECTION' named entity 'VACCINATION' named entity 'VACCINES' named entity 'SPIKE' named entity 'LATE' named entity 'ENTRY' named entity 'MATRIX' named entity 'ADJUVANT' named entity 'INDUCED' named entity 'NEUTRALIZING ANTIBODIES' named entity 'S PROTEIN' named entity 'IN VIVO' named entity 'INFECTIONS' named entity 'SPIKE' named entity '650' named entity 'RECEPTOR BINDING' named entity 'VIRION' named entity 'RECOMBINANT' named entity 'MICE' named entity 'GONE' named entity 'RESPONSIBLE' named entity 'TARGET' named entity 'APPROVED' named entity 'DEATHS' named entity 'MICE' named entity 'MERS-COV' named entity 'STUDY' named entity 'CURRENTLY' named entity 'MAKE' named entity 'TITER' named entity 'NANOPARTICLES' named entity 'INFECTION' named entity 'COMBINATION' named entity 'VACCINATIONS' named entity '2012' named entity 'discovered' named entity 'vivo' named entity 'The Middle' named entity 'neutralizing antibody' named entity 'Middle East respiratory syndrome' named entity 'protein' named entity 'infection' named entity 'vaccination' named entity 'vaccine' named entity 'mice' named entity 'vaccines' named entity 'infection' named entity 'mice' named entity 'spike (S) protein' named entity 'nanoparticles' named entity 'MERS-CoV' named entity 'virus' named entity 'NIH' named entity 'MERS-CoV' named entity 'infection' named entity 'Middle East respiratory syndrome coronavirus' named entity 'vaccines'

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