About: Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016

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About: Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016
source	Medline; PMC
abstract	OBJECTIVES: Human metapneumovirus (HMPV) is one of the most important respiratory viral pathogens affecting infants and children worldwide. Our study describes the epidemiological and clinical characteristics of HMPV present in patients hospitalised with acute respiratory illness (ARI) in Guangzhou, Southern China. STUDY DESIGN: A cross-sectional study. SETTING: Two tertiary hospitals in Guangzhou. PARTICIPANTS AND METHODS: Throat swabs were collected over a 3-year period from 5133 paediatric patients (≤14 years) hospitalised with ARI. Patients who are HMPV positive with clinical presentations (101/103) were recorded for further analysis. RESULTS: Of the 5133 patients included in the study, 103 (2.0%) were positive for HMPV. HMPV was more prevalent in children ≤5 years (2.2%, 98/4399) compared with older children (>5–14 years) (0.7%, 5/734) (P=0.004). Two seasonal HMPV peaks were observed each year and mainly occurred in spring and early summer. Overall, 18.4% (19/103) of patients who are HMPV positive were codetected with other pathogens, most frequently respiratory syncytial virus (36.8%, 7/19). Patients who are HMPV positive presented with a wide spectrum of clinical features, including cough (100.0%, 101/101), abnormal pulmonary breath sound (91.1%, 92/101), fever (88.1%, 89/101), expectoration (77.2%, 78/101), coryza (50.5%, 51/101) and wheezing (46.5%, 47/101). The main diagnosis of patients who are HMPV positive was bronchopneumonia (66.7%, 56/84). Fever (≥38˚C) (91.6%, 76/83) was detected more often in patients with only HMPV detected than in patients with HMPV plus other pathogen(s) detected (72.2%, 13/18) (P=0.037), whereas diarrhoea was more common in patients with HMPV plus other pathogen(s) detected (22.2%, 4/18), compared with patients with HMPV only (3.6%, 3/83) (P=0.018). CONCLUSIONS: HMPV is an important respiratory pathogen in children with ARI in Guangzhou, particularly in children ≤5 years old. HMPV has a seasonal variation. Bronchopneumonia is a major diagnosis in patients who are HMPV positive.
has issue date	2018-02-06(xsd:dateTime)
bibo:doi	10.1136/bmjopen-2017-019308
bibo:pmid	29437754
has license	cc-by
sha1sum (hex)	a741e03f654d2e7de5c7e94ff6e55be6a6bc0607
schema:url	https://doi.org/10.1136/bmjopen-2017-019308
resource representing a document's title	Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016
has PubMed Central identifier	PMC5829904
has PubMed identifier	29437754
schema:publication	BMJ Open
resource representing a document's body	covid:a741e03f654d2e7de5c7e94ff6e55be6a6bc0607#body_text
is schema:about of	named entity 'HISTORY' named entity 'PEER REVIEW' named entity 'HMPV' named entity 'young children' named entity 'HMPV' named entity 'epidemic' named entity 'pneumonia' named entity 'diarrhea' named entity 'significant difference' named entity 'line 328' named entity 'breath sound' named entity 'CXR' named entity 'clinical presentation' named entity 'viruses' named entity 'HMPV' named entity 'social activity' named entity 'Chest radiography' named entity 'PCR' named entity 'pneumonia' named entity 'pathogens' named entity 'pharyngeal' named entity 'pharyngeal' named entity 'HMPV' named entity 'attending physician' named entity 'nasal obstruction' named entity 'China' named entity 'sample size' named entity 'social activity' named entity 'sample size' named entity 'p-value' named entity 'infection' named entity 'bronchiolitis' named entity 'aetiology' named entity 'HMPV' named entity 'bronchopneumonia' named entity 'HMPV' named entity 'RNA' named entity 'standard of care' named entity 'attending physician' named entity 'pneumonia' named entity 'HMPV' named entity 'HMPV' named entity 'young children' named entity 'dizziness' named entity 'patients' medical records' named entity 'CXR' named entity 'clinical situation' named entity 'real-time PCR instrument' named entity 'Life Technologies' named entity 'fever' named entity 'influenza-like' named entity 'incidence rate' named entity 'HMPV' named entity 'HMPV' named entity 'reverse transcription' named entity 'respiratory symptoms' named entity 'epidemiology' named entity 'public health' named entity 'pathogen' named entity 'sample size' named entity 'HMPV' named entity 'pneumonia' named entity 'fever' named entity 'HMPV' named entity 'clinical presentation' named entity 'pneumonia' named entity 'LRTI' named entity 'coryza' named entity 'epidemiological' named entity 'auscultation' named entity 'coryza' named entity 'myalgia' named entity 'young children' named entity 'pharyngeal' named entity 'HMPV' named entity 'clinical characteristics' named entity 'pathogens' named entity 'HMPV' named entity 'breath sounds' named entity 'pathogens' named entity 'HMPV' named entity 'auscultation'

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