About: Identification of an endocytic signal essential for the antiviral action of IFITM3

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About: Identification of an endocytic signal essential for the antiviral action of IFITM3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of an endocytic signal essential for the antiviral action of IFITM3
Creator	Jia, Rui Liang, Chen Liu, Shan-Lu Qiao, Wentao Miao, Chunhui Zheng, Yi-Min Geng, Yunqi Yao, Yunfang Qian, Jin Guo, Fei Xu, Fengwen
Source	Medline; PMC
abstract	Members of the interferon-induced transmembrane (IFITM) protein family inhibit the entry of a wide range of viruses. Viruses often exploit the endocytosis pathways to invade host cells and escape from the endocytic vesicles often in response to low pH. Localization to these endocytic vesicles is essential for IFITM3 to interfere with the cytosolic entry of pH-dependent viruses. However, the nature of the sorting signal that targets IFITM3 to these vesicles is poorly defined. In this study, we report that IFITM3 possesses a YxxΦ sorting motif, i.e., 20-YEML-23, that enables IFITM3 to undergo endocytosis through binding to the μ2 subunit of the AP-2 complex. IFITM3 accumulates at the plasma membrane as a result of either mutating 20-YEML-23, depleting the μ2 subunit, or overexpressing μ2 mutants. Importantly, blocking endocytosis of IFITM3 abrogates its ability to inhibit pH-dependent viruses. We have therefore identified a critical sorting signal, namely 20-YEML-23, that controls both the endocytic trafficking and the antiviral action of IFITM3. This finding also reveals that as an endocytic protein, IFITM3 first arrives at the plasma membrane before it is endocytosed and further traffics to the late endosomes where it acts to impede virus entry.
has issue date	2014-02-13(xsd:dateTime)
bibo:doi	10.1111/cmi.12262
bibo:pmid	24521078
has license	green-oa
sha1sum (hex)	a7156becf1267cc8dc1f0ef5bc6c8df26e40debd
schema:url	https://doi.org/10.1111/cmi.12262
resource representing a document's title	Identification of an endocytic signal essential for the antiviral action of IFITM3
has PubMed Central identifier	PMC4065222
has PubMed identifier	24521078
schema:publication	Cellular Microbiology
resource representing a document's body	covid:a7156becf1267cc8dc1f0ef5bc6c8df26e40debd#body_text
is schema:about of	named entity 'sorting signal' named entity 'Localization' named entity 'endocytosis' named entity 'virus' named entity 'transmembrane' named entity 'INTERFERE' named entity 'WHERE' named entity 'EITHER' named entity 'ENDOSOMES' named entity 'BC2' named entity 'SUBUNIT' named entity 'EXPLOIT' named entity 'SIGNAL' named entity 'SORTING' named entity 'RESPONSE TO' named entity 'CYTOSOLIC' named entity 'ANTIVIRAL ACTION' named entity 'INVADE' named entity 'ESCAPE' named entity 'IDENTIFIED' named entity 'NIH' named entity 'BLOCKING' named entity 'IDENTIFICATION' named entity 'MUTANTS' named entity 'DEPLETING' named entity 'LOCALIZATION' named entity 'LOW PH' named entity 'WIDE' named entity 'ACTS' named entity 'SIGNAL' named entity 'ANTIVIRAL ACTION' named entity 'ACCESS' named entity 'IFITM3' named entity 'BINDING' named entity 'INTERFERON' named entity 'PH-' named entity 'ESSENTIAL' named entity 'TO INHIBIT' named entity 'INDUCED' named entity 'DEPENDENT' named entity 'FINDING' named entity 'PLASMA MEMBRANE' named entity 'TRANSMEMBRANE' named entity 'PROTEIN FAMILY' named entity 'HOST CELLS' named entity 'ENABLES' named entity 'TRAFFICKING' named entity 'PUBLIC' named entity 'VESICLES' named entity 'PATHWAYS' named entity 'POSSESSES' named entity 'RANGE' named entity 'PROTEIN' named entity 'REVEALS' named entity 'HAVE' named entity 'VIRUS ENTRY' named entity 'MOTIF' named entity 'MEMBERS' named entity 'STUDY' named entity 'AS A RESULT OF' named entity 'THESE' named entity 'CRITICAL' named entity 'ENDOCYTOSIS' named entity 'REPORT' named entity 'ESSENTIAL' named entity 'ITS' named entity 'IFITM3' named entity 'AP-2 COMPLEX' named entity 'LATE' named entity 'POORLY DEFINED' named entity 'ENTRY'

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