About: Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV)

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About: Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV)
Creator	Brownlie, Joe Erles, Kerstin Priestnall, Simon Mitchell, Judy Brooks, Harriet
source	Elsevier; Medline; PMC
abstract	One of the first lines of defence against viral infection is the innate immune response and the induction of antiviral type I interferons (IFNs). However some viruses, including the group 2 coronaviruses, have evolved mechanisms to overcome or circumvent the host antiviral response. Canine respiratory coronavirus (CRCoV) has previously been shown to have a widespread international presence and has been implicated in outbreaks of canine infectious respiratory disease (CIRD). This study aimed to quantify pro-inflammatory cytokine mRNAs following infection of canine air-interface tracheal cultures with CRCoV. Within this system, immunohistochemistry identified ciliated epithelial and goblet cells as positive for CRCoV, identical to naturally infected cases, thus the data obtained would be fully transferable to the situation in vivo. An assay of ciliary function was used to assess potential effects of CRCoV on the mucociliary system. CRCoV was shown to reduce the mRNA levels of the pro-inflammatory cytokines TNF-α and IL-6 and the chemokine IL-8 during the 72 h post-inoculation. The mechanism for this is unknown, however the suppression of a key antiviral strategy during a period of physiologic and immunological stress, such as on entry to a kennel, could potentially predispose a dog to further pathogenic challenge and the development of respiratory disease.
has issue date	2009-01-15(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2008.09.017
bibo:pmid	18977539
has license	no-cc
sha1sum (hex)	a6e619c0ffadbef3bb6d0802d9952290f1d6b6f2
schema:url	https://doi.org/10.1016/j.vetimm.2008.09.017
resource representing a document's title	Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV)
has PubMed Central identifier	PMC7112596
has PubMed identifier	18977539
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:a6e619c0ffadbef3bb6d0802d9952290f1d6b6f2#body_text
is schema:about of	named entity 'TRACHEAL EPITHELIUM' named entity 'QUANTIFICATION' named entity 'coronavirus' named entity 'ciliary' named entity 'MRNA' named entity 'FUNCTION' named entity 'CILIARY' named entity 'CYTOKINES' named entity 'CANINE RESPIRATORY CORONAVIRUS' named entity 'CHEMOKINES' named entity 'ENCODING' named entity 'CANINE' named entity 'ASSESSMENT' named entity 'INFECTION' named entity 'infection' named entity 'CRCoV' named entity 'coronavirus' named entity 'cytokines' named entity 'mRNA' named entity 'tracheal' named entity 'infection' named entity 'canine' named entity 'chemokines' named entity 'canine' named entity 'epithelium' named entity 'tracheal' named entity 'respiratory' named entity 'cytokines' named entity 'canine' named entity 'canine' named entity 'encoding' named entity 'epithelium' named entity 'function' named entity 'chemokines' named entity 'mRNA'
is part of of	Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV) covid:a6e619c0ffadbef3bb6d0802d9952290f1d6b6f2#body_text One of the first lines of defence against viral infection is the innate immune response and the induction of antiviral type I interferons (IFNs). However some viruses, including the group 2 coronaviruses, have evolved mechanisms to overcome or circumvent the host antiviral response. Canine respiratory coronavirus (CRCoV) has previously been shown to have a widespread international presence and has been implicated in outbreaks of canine infectious respiratory disease (CIRD). This study aimed to quantify pro-inflammatory cytokine mRNAs following infection of canine air-interface tracheal cultures with CRCoV. Within this system, immunohistochemistry identified ciliated epithelial and goblet cells as positive for CRCoV, identical to naturally infected cases, thus the data obtained would be fully transferable to the situation in vivo. An assay of ciliary function was used to assess potential effects of CRCoV on the mucociliary system. CRCoV was shown to reduce the mRNA levels of the pro-inflammatory cytokines TNF-α and IL-6 and the chemokine IL-8 during the 72 h post-inoculation. The mechanism for this is unknown, however the suppression of a key antiviral strategy during a period of physiologic and immunological stress, such as on entry to a kennel, could potentially predispose a dog to further pathogenic challenge and the development of respiratory disease.

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