About: UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the Covid-19 Pandemic

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About: UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the Covid-19 Pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the Covid-19 Pandemic
Creator	Card, Kyle Crozier, Dena Dhawan, Andrew Dinh, Mina Division, Theory Dolson, Emily Farrokhian, Nathan Gopalakrishnan, Vishhvaan Ho, Emily King, Eshan Krishnan, Nikhil Kuzmin, Gleb Maltas, Jeff Pelesko, Julia Scarborough, Jessica Scott, Jacob Sedor, Geoff Weaver, Davis
Source	MedRxiv
abstract	Personal protective equipment (PPE), including surgical masks and N95 respirators, is crucially important to the safety of both patients and medical personnel, particularly in the event of infectious pandemics. As the incidence of Coronavirus Disease (COVID-19) is increasing exponentially in the United States and worldwide, healthcare provider demand for these necessities is currently outpacing supply. As such, strategies to safely expand the lifespan of the supply of medical equipment are critically important. In the recent days, weeks, and months, in the midst of the current pandemic, there has been a concerted effort to identify viable ways to conserve Personal Protective Equipment, including sterilization after use. Some hospitals have already begun using UV-C light to sterilize N95 respirators, but many lack the space or equipment to implement existing protocols. In this study, we outline a procedure by which N95 respirators may be sterilized using ultraviolet (UV) radiation in biosafety cabinets (BSCs), a common element of many academic, public health, and hospital laboratories. The primary obstacle to this approach is the possibility the UV radiation levels vary within BSCs. To account for this potential variation in dosing across the base of the BSC, we tested the UV-C radiation in two randomly chosen idle BSCs in our research institute and observed a maximum ratio between the minimum and maximum recorded intensities within a given BSC to be 1.98. Based on these values, we calculated that an N95 mask placed within a BSC with a manufacturer reported fluence of 100 W/cm^2 should be effectively sanitized for reuse after approximately 15-20 minutes per side. Our results provide support to healthcare organizations looking for alternative methods to extend their reserves of PPE. It is our hope that with an easily implemented strategy, as we have presented here, idle BSCs can be utilized to alleviate the PPE shortage by providing a way to sterilize PPE to allow safe daily re-use. This should be tested on a larger scale, and confirmed in a virology laboratory before adoption, though we contend that in extremis, this method would be preferred compared to re-use without sterilization.
has issue date	2020-03-27(xsd:dateTime)
bibo:doi	10.1101/2020.03.25.20043489
has license	medrxiv
sha1sum (hex)	a6109bded27f2f1c55036186c8284d85af55b2c5
schema:url	https://doi.org/10.1101/2020.03.25.20043489
resource representing a document's title	UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the Covid-19 Pandemic
resource representing a document's body	covid:a6109bded27f2f1c55036186c8284d85af55b2c5#body_text
is schema:about of	named entity 'Laboratory' named entity 'ALLOW' named entity 'SCHOOL' named entity 'conservation' named entity 'vetting' named entity 'releasing' named entity 'COVID-19' named entity 'Sterilization' named entity 'Biosafety' named entity 'dire' named entity 'FFRs' named entity 'irradiance' named entity 'N95 respirators' named entity 'ggplot2' named entity 'N95 respirators' named entity 'open source' named entity 'SARS-CoV-2 virus' named entity 'sterilization' named entity 'radiation dose' named entity 'PPE' named entity 'respiratory droplets' named entity 'sterilization' named entity 'medRxiv' named entity 'respiratory droplets' named entity 'disinfection' named entity 'peer reviewed' named entity 'pathogens' named entity 'sterilization' named entity 'PPE' named entity 'PPE' named entity 'Type A2' named entity 'electromagnetic radiation' named entity 'medRxiv' named entity 'N95 mask' named entity 'sterilization' named entity 'ssRNA' named entity 'sterilization' named entity 'United States' named entity 'UV light' named entity 'single-stranded RNA' named entity 'airborne particles' named entity 'voltage' named entity 'UV-C' named entity 'PPE' named entity 'Lerner Research' named entity 'UV-C' named entity 'photodiodes' named entity 'viruses' named entity 'UVGI' named entity 'COVID-19' named entity 'Cleveland Clinic' named entity 'social distancing' named entity 'UV lights' named entity 'upper bound' named entity 'UV-C' named entity 'transmittance' named entity 'sterilizing' named entity 'peer review' named entity 'technical replicates' named entity 'photodiodes' named entity 'Case Western Reserve University School of Medicine' named entity 'Enrico Fermi' named entity 'N95 respirators' named entity 'visible light' named entity 'sterilization' named entity 'sterility' named entity 'single-stranded RNA' named entity 'medRxiv'

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