About: The multifaceted role of plasminogen in inflammation

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About: The multifaceted role of plasminogen in inflammation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The multifaceted role of plasminogen in inflammation
Creator	Takahashi, Satoshi Hattori, Koichi Heissig, Beate Osada, Taro Salama, Yousef
Source	Elsevier; PMC
abstract	A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted to the serine protease plasmin, a key fibrinolytic factor by plasminogen activators including tissue-type plasminogen activator (tPA). Plasmin is part of an intricate protease network controlling proteins of initial hemostasis/coagulation, fibrinolytic and complement system. Activation of these protease cascades is required to mount a proper inflammatory response. Although best known for its ability to dissolve clots and cleave fibrin, recent studies point to the importance of fibrin-independent functions of plasmin during acute inflammation and inflammation resolution. In this review, we provide an up-to-date overview of the current knowledge of the enzymatic and cytokine-like effects of tPA and describe the role of tPA and plasminogen receptors in the regulation of the inflammatory response with emphasis on the cytokine storm syndrome such as observed during coronavirus disease 2019 or macrophage activation syndrome. We discuss tPA as a modulator of Toll like receptor signaling, plasmin as an activator of NFkB signaling, and summarize recent studies on the role of plasminogen receptors as controllers of the macrophage conversion into the M2 type and as mediators of efferocytosis during inflammation resolution.
has issue date	2020-08-28(xsd:dateTime)
bibo:doi	10.1016/j.cellsig.2020.109761
has license	no-cc
sha1sum (hex)	a5ebb4f3ddbb6c2c1446849b895958ae528b647a
schema:url	https://doi.org/10.1016/j.cellsig.2020.109761
resource representing a document's title	The multifaceted role of plasminogen in inflammation
has PubMed Central identifier	PMC7452830
schema:publication	Cell Signal
resource representing a document's body	covid:a5ebb4f3ddbb6c2c1446849b895958ae528b647a#body_text
is schema:about of	named entity 'initial' named entity 'tPA' named entity 'smooth muscle cells' named entity 'Journal' named entity 'type' named entity 'tPA' named entity 'LRP1' named entity 'granulocyte-macrophage colony-stimulating factor' named entity 'serine protease' named entity 'controlling' named entity 'activated' named entity 'inflammation' named entity 'Journal' named entity 'studies' named entity 'function' named entity 'protease' named entity 'proper' named entity 'functions' named entity 'protease' named entity 'controllers' named entity 'studies' named entity 'factors' named entity 'describe' named entity 'receptor' named entity 'platelets' named entity 'plasminogen' named entity 'activator' named entity 'modulator' named entity 'plasmin' named entity 'chemokines' named entity 'macrophage' named entity 'hemostasis' named entity 'smooth muscle cells' named entity 'platelets' named entity 'granulocyte-macrophage colony-stimulating factor' named entity 'proteases' named entity 'coagulation' named entity 'plasmin' named entity 'fibrin' named entity 'complement' named entity 'mononuclear cells' named entity 'efferocytosis' named entity 'Plasmin' named entity 'plasminogen' named entity 'phagocytosis' named entity 'inflammation' named entity 'inflammatory response' named entity 'Plasmin' named entity 'NFkB' named entity 'fibrinolytic factor' named entity 'Pharmacological' named entity 'MMPs' named entity 'Tissue damage' named entity 'fibrin' named entity 'Lysine' named entity 'brain injury' named entity 'TLR9' named entity 'interferon regulatory factor 3' named entity 'Factor XII' named entity 'adhesive' named entity 'uPA' named entity 'extracellular' named entity 'presenilin' named entity 'protein' named entity 'vicious cycle' named entity 'Toll-like receptor' named entity 'Plg' named entity 'inflammatory disease' named entity 'TNFa' named entity 'peripheral nerve injury' named entity 'polyphosphates' named entity 'Plg' named entity 'fibrin' named entity 'proteolytic' named entity 'bradykinin' named entity 'Respiratory symptoms' named entity 'lysine' named entity 'Vascular endothelial cells' named entity 'complement'

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