About: Magnetic Lateral Flow Immunoassays

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Magnetic Lateral Flow Immunoassays
Creator	Carlos Martínez-García, José Carmen Blanco-López, M Moyano, Amanda Rivas, Montserrat Salvador, María Serrano-Pertierra, Esther
topic	covid:a5c8836243c91ec9b97900f1e125b8faa08f2af7#this
Source	Medline; PMC
abstract	A new generation of magnetic lateral flow immunoassays is emerging as powerful tool for diagnostics. They rely on the use of magnetic nanoparticles (MNP) as detecting label, replacing conventional gold or latex beads. MNPs can be sensed and quantified by means of external devices, allowing the development of immunochromatographic tests with a quantitative capability. Moreover, they have an added advantage because they can be used for immunomagnetic separation (IMS), with improvements in selectivity and sensitivity. In this paper, we have reviewed the current knowledge on magnetic-lateral flow immunoassay (LFIA), coupled with both research and commercially available instruments. The work in the literature has been classified in two categories: optical and magnetic sensing. We have analysed the type of magnetic nanoparticles used in each case, their size, coating, crystal structure and the functional groups for their conjugation with biomolecules. We have also taken into account the analytical characteristics and the type of transduction. Magnetic LFIA have been used for the determination of biomarkers, pathogens, toxins, allergens and drugs. Nanocomposites have been developed as alternative to MNP with the purpose of sensitivity enhancement. Moreover, IMS in combination with other detection principles could also improve sensitivity and limit of detection. The critical analysis in this review could have an impact for the future development of magnetic LFIA in fields requiring both rapid separation and quantification.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.3390/diagnostics10050288
bibo:pmid	32397264
has license	cc-by
sha1sum (hex)	a5c8836243c91ec9b97900f1e125b8faa08f2af7
schema:url	https://doi.org/10.3390/diagnostics10050288
resource representing a document's title	Magnetic Lateral Flow Immunoassays
has PubMed Central identifier	PMC7278001
has PubMed identifier	32397264
schema:publication	Diagnostics (Basel)
resource representing a document's body	covid:a5c8836243c91ec9b97900f1e125b8faa08f2af7#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/a5c8836243c91ec9b97900f1e125b8faa08f2af7
is schema:about of	named entity 'SELECTIVITY' named entity 'RESEARCH' named entity 'MNP' named entity 'TAKEN' named entity 'ALTERNATIVE' named entity 'BIOMOLECULES' named entity 'QUANTIFICATION' named entity 'CURRENT' named entity 'GENERATION' named entity 'MAGNETIC' named entity 'LATERAL' named entity 'biomarkers' named entity 'pathogens' named entity 'nanoparticles' named entity '10 nm' named entity 'selenium' named entity 'antibodies' named entity 'electrical resistivity' named entity 'analyte' named entity 'chloramphenicol' named entity 'ng/mL' named entity 'nanoparticles' named entity 'biomarker' named entity 'Colloidal' named entity 'Carboxyl groups' named entity 'functional groups' named entity 'bioconjugation' named entity 'carbodiimide' named entity 'pg/mL' named entity 'ng/mL' named entity 'Campylobacter jejuni' named entity 'Fluorescent' named entity 'Nanocomposites' named entity 'nanoparticles' named entity 'phosphor' named entity 'Gold nanoparticles' named entity 'virus' named entity 'Health systems' named entity 'E. coli O157:H7' named entity 'fluorescent' named entity 'nanoparticles' named entity 'hormones' named entity 'limit of detection' named entity 'limits of detection' named entity 'nanoparticles' named entity 'analytical parameters' named entity 'protein' named entity 'black line' named entity 'positively charged' named entity 'morphology' named entity 'Colloidal' named entity 'gold nanoparticles' named entity 'ionic interactions' named entity 'self-inductance' named entity 'nanoparticles' named entity 'synergistically' named entity 'localized surface plasmon resonance' named entity 'biotin' named entity 'limits of detection' named entity 'Salmonella' named entity 'Chemistry' named entity 'quantum dots' named entity 'pg/mL' named entity 'microspheres' named entity 'pg/mL' named entity 'impedance' named entity '10.5' named entity 'nitrocellulose' named entity 'plastic' named entity 'Escherichia coli O157:H7' named entity 'pregnancy test' named entity 'nanoparticle' named entity 'Superparamagnetic' named entity 'POCT'

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