About: Binding of porcine transmissible gastroenteritis virus by enterocytes from newborn and weaned piglets

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About: Binding of porcine transmissible gastroenteritis virus by enterocytes from newborn and weaned piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Binding of porcine transmissible gastroenteritis virus by enterocytes from newborn and weaned piglets
Creator	Derbyshire, J Weingartl, H
Source	PMC
abstract	Enterocytes were harvested by chelation in a series of seven fractions from the tips of the villi to the crypts of the jejunum of newborn or weaned piglets. Binding of the low cell culture passaged Miller-6 strain of transmissible gastroenteritis virus (TGEV) to villous enterocytes from newborn piglets was at a high level, similar to that observed to culturedswine test is (ST) cells. Binding of the virus to cryptal enterocytes from newborn piglets or to villous or cryptal enterocytes from weaned piglets was significantly lower. In a competitive virus binding assay with radiolabelled virus, the binding of TGEV to ST cells was found to be saturable, while binding to MDBK cells, in which the virus fails to replicate, was at a lower level and was non-saturable. In the same assay, virus binding to the villous enterocytes from the jejunum of a newborn piglet was saturable, while binding to cryptal enterocytes from a newborn piglet, and to villous and cryptal enterocytes from a weaned piglet, was non-saturable. It was concluded that the high susceptibility of newborn piglets to TGEV infection, and the tropism of the virus for villous enterocytes, may relate to the presence of specific, saturable binding sites on the plasma membrane of villous enterocytes.
has issue date	2002-11-13(xsd:dateTime)
bibo:doi	10.1016/0378-1135(93)90113-l
bibo:pmid	8395743
has license	no-cc
sha1sum (hex)	a5c5bc90ac31c106aea3441e8a6ff858c20d6706
schema:url	https://doi.org/10.1016/0378-1135%2893%2990113-l
resource representing a document's title	Binding of porcine transmissible gastroenteritis virus by enterocytes from newborn and weaned piglets
has PubMed Central identifier	PMC7117419
has PubMed identifier	8395743
schema:publication	Vet Microbiol
resource representing a document's body	covid:a5c5bc90ac31c106aea3441e8a6ff858c20d6706#body_text
is schema:about of	named entity 'villous' named entity 'villous' named entity 'susceptibility' named entity 'enterocytes' named entity 'piglets' named entity 'piglets' named entity 'piglets' named entity 'transmissible' covid:arg/a5c5bc90ac31c106aea3441e8a6ff858c20d6706 named entity 'NEWBORN' named entity 'WEANED' named entity 'CELLS' named entity 'HIGH LEVEL' named entity 'VILLOUS' named entity 'ASSAY' named entity 'REPLICATE' named entity 'TESTIS' named entity 'OBSERVED' named entity 'VIRUS BINDING' named entity 'PRESENCE OF' named entity 'SWINE' named entity 'BINDING' named entity 'CHELATION' named entity 'ENTEROCYTES' named entity 'FRACTIONS' named entity 'FAILS' named entity 'CULTURED' named entity 'FOUND' named entity 'SERIES' named entity 'WEANED' named entity 'JEJUNUM' named entity 'TROPISM' named entity 'NEWBORN' named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'LEVEL' named entity 'VIRUS' named entity 'WEANED PIGLET' named entity 'BINDING' named entity 'LOW' named entity 'PLASMA MEMBRANE' named entity 'STRAIN' named entity 'ENTEROCYTES' named entity 'MILLER' named entity 'RELATE' named entity 'BINDING SITES' named entity 'COMPETITIVE' named entity 'LOWER' named entity 'NON-' named entity 'BINDING ASSAY' named entity 'SUSCEPTIBILITY' named entity 'MDBK' named entity 'SPECIFIC' named entity 'INFECTION' named entity 'SEVEN' named entity 'TIPS' named entity 'CELL CULTURE' named entity 'SIMILAR' named entity 'PIGLET' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'RADIOLABELLED' named entity 'HIGH' named entity 'assay' named entity 'weaned' named entity 'enterocytes' named entity 'virus' named entity 'swine' named entity 'newborn' named entity 'newborn' named entity 'testis' named entity 'assay' named entity 'saturable' named entity 'saturable' named entity 'transmissible gastroenteritis virus' named entity 'chelation' named entity 'saturable' named entity 'plasma membrane' named entity 'enterocytes' named entity 'enterocytes' named entity 'assay' named entity 'saturable'

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