About: Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study

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About: Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study
Creator	Feikin, Daniel Moore, David Ebruke, Bernard Morpeth, Susan Murdoch, David Antonio, Martin Goswami, Doli Prosperi, Christine Zaman, Khalequ Duncan, Julie Paveenkittiporn, Wantana Piralam, Barameht Sow, Samba Scott, G Madhi, Shabir Karron, Ruth Anthony, J Awori, Juliet Baggett, Henry Baillie, Vicky Brooks, W Deluca, Andrea Driscoll, Amanda Higdon, Melissa Howie, Stephen Knoll, Maria Kotloff, Karen Levine, Orin O'brien, Katherine Park, Daniel Thea, Donald Hammitt, Laura Tapia, Milagritos Watson, Nora Zeger, Scott Mulindwa, Justin
source	Medline; PMC
abstract	BACKGROUND: Previous studies suggested an association between upper airway pneumococcal colonization density and pneumococcal pneumonia, but data in children are limited. Using data from the Pneumonia Etiology Research for Child Health (PERCH) study, we assessed this potential association. METHODS: PERCH is a case-control study in 7 countries: Bangladesh, The Gambia, Kenya, Mali, South Africa, Thailand, and Zambia. Cases were children aged 1–59 months hospitalized with World Health Organization–defined severe or very severe pneumonia. Controls were randomly selected from the community. Microbiologically confirmed pneumococcal pneumonia (MCPP) was confirmed by detection of pneumococcus in a relevant normally sterile body fluid. Colonization density was calculated with quantitative polymerase chain reaction analysis of nasopharyngeal/oropharyngeal specimens. RESULTS: Median colonization density among 56 cases with MCPP (MCPP cases; 17.28 × 10(6) copies/mL) exceeded that of cases without MCPP (non-MCPP cases; 0.75 × 10(6)) and controls (0.60 × 10(6)) (each P < .001). The optimal density for discriminating MCPP cases from controls using the Youden index was >6.9 log(10) copies/mL; overall, the sensitivity was 64% and the specificity 92%, with variable performance by site. The threshold was lower (≥4.4 log(10) copies/mL) when MCPP cases were distinguished from controls who received antibiotics before specimen collection. Among the 4035 non-MCPP cases, 500 (12%) had pneumococcal colonization density >6.9 log(10) copies/mL; above this cutoff was associated with alveolar consolidation at chest radiography, very severe pneumonia, oxygen saturation <92%, C-reactive protein ≥40 mg/L, and lack of antibiotic pretreatment (all P< .001). CONCLUSIONS: Pneumococcal colonization density >6.9 log(10) copies/mL was strongly associated with MCPP and could be used to improve estimates of pneumococcal pneumonia prevalence in childhood pneumonia studies. Our findings do not support its use for individual diagnosis in a clinical setting.
has issue date	2017-05-27(xsd:dateTime)
bibo:doi	10.1093/cid/cix100
bibo:pmid	28575365
has license	bronze-oa
sha1sum (hex)	a5c17c1af17e4ff8b75ae721ad2b89286dafdc32
schema:url	https://doi.org/10.1093/cid/cix100
resource representing a document's title	Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study
has PubMed Central identifier	PMC5850437
has PubMed identifier	28575365
schema:publication	Clinical Infectious Diseases
resource representing a document's body	covid:a5c17c1af17e4ff8b75ae721ad2b89286dafdc32#body_text
is schema:about of	named entity 'NONTHABURI' named entity 'NAKHON PHANOM' named entity 'data' named entity 'OFFICE' named entity 'ASSOCIATION' named entity 'ETIOLOGY' named entity 'DENSITY' named entity 'CHILD HEALTH' named entity 'DATA' named entity 'USING' named entity 'PNEUMOCOCCAL' named entity 'STUDIES' named entity 'POTENTIAL' named entity 'CHILDREN' named entity 'PUBLIC HEALTH' named entity 'HEALTH' named entity 'UPPER AIRWAY' named entity 'PNEUMOCOCCAL PNEUMONIA' named entity 'RESEARCH' named entity 'LIMITED' named entity 'PNEUMONIA' named entity 'STUDY' named entity 'PREVIOUS' named entity 'BUT' named entity 'ASSESSED' named entity 'COLONIZATION' covid:arg/a5c17c1af17e4ff8b75ae721ad2b89286dafdc32 named entity 'Etiology' named entity 'studies' named entity 'Nonthaburi' named entity 'Child Health' named entity 'alveolar' named entity 'pneumococcus' named entity 'antibiotics' named entity 'oxygen saturation' named entity 'antibiotics' named entity 'pneumonia' named entity 'Kenya' named entity 'pneumococcal' named entity 'pneumococcal disease' named entity 'severe pneumonia' named entity 'South Africa' named entity 'Gambia' named entity 'pneumococcus' named entity 'PCV' named entity 'PCR analysis'

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