About: Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?
Creator	Macdonald, Andrew Carrasco, Luis Müller, Marietta Royle, Jamie Luis, José Dobson, Samuel
topic	covid:a599eb2c6ca51522fa234d8059f989569f4fe298#this
Source	PMC
abstract	Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention.
has issue date	2015-10-16(xsd:dateTime)
bibo:doi	10.3390/v7102880
bibo:pmid	26501313
has license	cc-by
sha1sum (hex)	a599eb2c6ca51522fa234d8059f989569f4fe298
schema:url	https://doi.org/10.3390/v7102880
resource representing a document's title	Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?
has PubMed Central identifier	PMC4632388
has PubMed identifier	26501313
schema:publication	Viruses
resource representing a document's body	covid:a599eb2c6ca51522fa234d8059f989569f4fe298#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/a599eb2c6ca51522fa234d8059f989569f4fe298
is schema:about of	named entity 'myriad' named entity 'HAVE' named entity 'GROWING' named entity 'FLOW' named entity 'MEMBRANE' named entity 'IONS' named entity 'ANTIVIRALS' named entity 'HOST' named entity 'DEVELOPMENTS' named entity 'THERAPEUTIC INTERVENTION' named entity 'LIFE CYCLES' named entity 'PROPERTIES' named entity 'TARGETS' named entity 'EMBEDDED' named entity 'STUDIES' named entity 'ESSENTIAL' named entity 'MEMBRANES' named entity 'LIFE CYCLE' named entity 'VIRAL' named entity 'CHANNEL' named entity 'LIKE' named entity 'SMALL' named entity 'VIROPORIN' named entity 'ACROSS' named entity 'TARGETS' named entity 'ROLES' named entity 'NOVEL' named entity 'ENCODED' named entity 'DNA VIRUSES' named entity 'PROCESSES' named entity 'REVIEW' named entity 'DISPLAY' named entity 'RANGE' named entity 'UNDERSTANDING' named entity 'ALL STAGES' named entity 'FORMING' named entity 'THEIR' named entity 'HIGHLY' named entity 'PATHOGENESIS' named entity 'THESE' named entity 'VIRUS' named entity 'DNA TUMOR VIRUSES' named entity 'ARTICLE' named entity 'MANIPULATING' named entity 'ENCODED' named entity 'CELLULAR' named entity 'HYDROPHOBIC' named entity 'NATURE' named entity 'MEDIATE' named entity 'CONTRIBUTE ' named entity 'NOVEL' named entity 'RNA VIRUSES' named entity 'SOLUTES' named entity 'PROTEINS' named entity 'IDENTIFIED' named entity 'ROLES' named entity 'A GROUP' named entity 'POTENTIAL' named entity 'NUMBER OF' named entity 'OUR' named entity 'RECENT' named entity 'NECESSARY' named entity 'therapeutic intervention' named entity 'embedded' named entity 'summarizes' named entity 'virus' named entity 'manipulating' named entity 'anti-viral' named entity 'Emerging' named entity 'solutes' named entity 'hydrophobic' named entity 'cellular membranes' named entity 'pathogenesis' named entity 'HPV infection'

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