About: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore

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About: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore
Creator	Habib, Abdulrazaq Singh, Kamaljit Ling, Ai-Ee Tambyah, Paul Ho, Khek Ooi, Eng Bai, Xin Sil, Bijon Lim, Tow Ong, Benjamin
Source	Medline; PMC
abstract	Background. Severe acute respiratory syndrome (SARS) is a newly recognized infectious disease that has recently emerged in East Asia and North America. Although the clinical features of acute infection have been well described, mildly symptomatic or asymptomatic infections have not been well characterized. Objective. To assess the spectrum of illness in health-care workers (HCWs). Methods. A prospective seroepidemiologic cohort study was conducted on 372 HCWs in a large teaching hospital in Singapore who were both exposed and not exposed to patients with SARS. Participating HCWs completed a questionnaire and provided paired serum samples, which were analyzed by 2 different laboratories blinded to clinical data, by use of an enzyme-linked immunosorbent assay based on a protocol developed by the Centers for Disease Control and Prevention and a dot-blot immunoassay, with confirmation by a viral neutralization assay. Results. A total of 21 patients with SARS were treated at our hospital. They were associated with transmission to 14 staff members, patients, and visitors in our hospital. Of the 372 HCWs participating in the present study, 8 were found to have positive antibodies to the SARS coronavirus in both samples by use of both test methods, and 6 had pneumonia and had been hospitalized for either probable or suspected SARS infection, whereas 2 had fever but did not have changes on chest radiographs. All seropositive HCWs had been exposed either directly or indirectly to patients with SARS. No asymptomatic, nonexposed staff members were found to be seropositive. There was a trend towards protection for HCWs who, while fully protected, had had contact with patients with SARS. Conclusions. Although the majority of cases of SARS are associated with pneumonia, a small number of mildly symptomatic individuals do seroconvert. HCWs who are exposed to patients with SARS can be infected with SARS, regardless of the intensity of exposure. This has implications for surveillance and infection control planning, in the event that SARS returns next winter.
has issue date	2004-02-01(xsd:dateTime)
bibo:doi	10.1086/381558
bibo:pmid	14767817
has license	no-cc
sha1sum (hex)	a57cae0aa947c4e3fcfa5c395a02981470636ef7
schema:url	https://doi.org/10.1086/381558
resource representing a document's title	Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore
has PubMed Central identifier	PMC7109818
has PubMed identifier	14767817
schema:publication	J Infect Dis
resource representing a document's body	covid:a57cae0aa947c4e3fcfa5c395a02981470636ef7#body_text
is schema:about of	named entity 'CORONAVIRUS INFECTION' named entity 'East Asia' named entity 'acute infection' named entity 'North America' named entity 'Severe Acute Respiratory Syndrome Coronavirus' named entity 'Lessons' named entity 'PROSPECTIVE' named entity 'HEALTH' named entity 'NORTH AMERICA' named entity 'MILD' named entity 'SEROEPIDEMIOLOGIC STUDY' named entity 'ILLNESS' named entity 'CARE' named entity 'IS A' named entity 'ASSOCIATED WITH' named entity 'WORKERS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CLINICAL FEATURES' named entity 'ACUTE INFECTION' named entity 'NEWLY' named entity 'SYMPTOMATIC' named entity 'SINGAPORE' named entity 'INFECTIOUS DISEASE' named entity 'EAST ASIA' named entity 'TEACHING HOSPITAL' named entity 'HAVE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'CHARACTERIZED' named entity 'RECENTLY' named entity 'MILDLY' named entity 'ASYMPTOMATIC INFECTIONS' named entity 'DESCRIBED' covid:arg/a57cae0aa947c4e3fcfa5c395a02981470636ef7 named entity 'asymptomatic' named entity 'Singapore' named entity 'East Asia' named entity 'infectious disease' named entity 'asymptomatic infections' named entity 'Singapore' named entity 'dot-blot' named entity 'SARS coronavirus' named entity 'infection' named entity 'SARS' named entity 'Singapore' named entity 'virus' named entity 'allied health professionals' named entity 'SPSS' named entity 'SARS' named entity 'SARS' named entity 'China' named entity 'Nipah virus' named entity 'titer' named entity 'SARS' named entity 'SARS' named entity 'screening tests' named entity 'animal reservoir' named entity 'SPSS' named entity 'fever' named entity 'SARS' named entity 'seroconversion' named entity 'HCW' named entity 'serum samples' named entity 'immunofluorescence assay' named entity 'health-care' named entity 'serum' named entity 'body fluids' named entity 'mainland China' named entity 'SARS' named entity 'seropositive' named entity 'asymptomatic' named entity 'WHO' named entity 'chills'

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