About: Ebola virus disease and critical illness

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ebola virus disease and critical illness
Creator	Portella, Gina Fowler, Robert Murthy, Srinivas Jacobs, Michael Chan, Adrienne Rubinson, Lewis Ferri, Mauricio Uyeki, Timothy Shindo, Nikki Brett-Major, David Clement, Christophe Crozier, Ian Dickson, Stuart Hajek, Jan Lamah, Marie-Claire Lamontagne, Francois Leligdowicz, Aleksandra Mishra, Sharmistha Vanderschuren, Abel Bausch, Daniel Adhikari, Neill Fischer Ii, William Fletcher, Thomas Iii, Lyon Jacob, Shevin Marshall, G O'dempsey, Tim Schieffelin, John
Source	PMC
abstract	As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flare-ups of EVD cases in West Africa. EVD presentation is nonspecific and characterized initially by onset of fatigue, myalgias, arthralgias, headache, and fever; this is followed several days later by anorexia, nausea, vomiting, diarrhea, and abdominal pain. Anorexia and gastrointestinal losses lead to dehydration, electrolyte abnormalities, and metabolic acidosis, and, in some patients, acute kidney injury. Hypoxia and ventilation failure occurs most often with severe illness and may be exacerbated by substantial fluid requirements for intravascular volume repletion and some degree of systemic capillary leak. Although minor bleeding manifestations are common, hypovolemic and septic shock complicated by multisystem organ dysfunction appear the most frequent causes of death. Males and females have been equally affected, with children (0–14 years of age) accounting for 19 %, young adults (15–44 years) 58 %, and older adults (≥45 years) 23 % of reported cases. While the current case fatality proportion in West Africa is approximately 40 %, it has varied substantially over time (highest near the outbreak onset) according to available resources (40–90 % mortality in West Africa compared to under 20 % in Western Europe and the USA), by age (near universal among neonates and high among older adults), and by Ebola viral load at admission. While there is no Ebola virus-specific therapy proven to be effective in clinical trials, mortality has been dramatically lower among EVD patients managed with supportive intensive care in highly resourced settings, allowing for the avoidance of hypovolemia, correction of electrolyte and metabolic abnormalities, and the provision of oxygen, ventilation, vasopressors, and dialysis when indicated. This experience emphasizes that, in addition to evaluating specific medical treatments, improving the global capacity to provide supportive critical care to patients with EVD may be the greatest opportunity to improve patient outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13054-016-1325-2) contains supplementary material, which is available to authorized users.
has issue date	2016-07-29(xsd:dateTime)
bibo:doi	10.1186/s13054-016-1325-2
bibo:pmid	27468829
has license	cc-by
sha1sum (hex)	a52fd1386e8a463e46bde0e66125bfd826a64f56
schema:url	https://doi.org/10.1186/s13054-016-1325-2
resource representing a document's title	Ebola virus disease and critical illness
has PubMed Central identifier	PMC4965892
has PubMed identifier	27468829
schema:publication	Crit Care
resource representing a document's body	covid:a52fd1386e8a463e46bde0e66125bfd826a64f56#body_text
is schema:about of	named entity 'proven' named entity 'EVD' named entity '45 years' named entity 'frequent' named entity 'accounting' named entity 'fatigue' named entity 'fluid' covid:arg/a52fd1386e8a463e46bde0e66125bfd826a64f56 named entity 'gastrointestinal' named entity 'While' named entity 'improve' named entity 'young adults' named entity 'clinical trials' named entity 'diarrhea' named entity 'neonates' named entity 'Males' named entity 'hypovolemic' named entity 'cases' named entity 'vasopressors' named entity 'bleeding' named entity 'time' named entity 'evaluating' named entity 'sporadic' named entity 'dehydration' named entity 'lead' named entity 'degree' named entity 'metabolic abnormalities' named entity 'abdominal pain' named entity 'acute kidney injury' named entity 'nausea' named entity 'medical treatments' named entity 'vomiting' named entity 'intensive care' named entity 'West Africa' named entity 'neonates' named entity 'Ebola virus disease' named entity 'EVD' named entity 'arthralgias' named entity 'hypovolemia' named entity 'virus' named entity 'global capacity' named entity 'age' named entity 'capillary' named entity 'fluid resuscitation' named entity 'diagnostic testing' named entity 'vaccine' named entity 'levels of care' named entity 'morbidity' named entity 'organ dysfunction' named entity 'EVD' named entity 'fluid balance' named entity 'West Africa' named entity 'Ebola' named entity 'virus'

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