About: Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children

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About: Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children
Creator	Rossen, John Madhi, Shabir Kuschner, Zachary Kuwanda, Locadiah Madimabe, Richard Moloi, Jackie Rabede, Zelda Adrian, Peter Klugman, Keith Nunes, Marta Niekerk, Nadia
Source	Medline; PMC
abstract	BACKGROUND: Advances in molecular diagnostics have implicated newly-discovered respiratory viruses in the pathogenesis of pneumonia. We aimed to determine the prevalence and clinical characteristics of human bocavirus (hBoV), human rhinovirus (hRV), polyomavirus-WU (WUPyV) and –KI (KIPyV) and human coronaviruses (CoV)-OC43, -NL63, -HKU1 and -229E among children hospitalized with lower respiratory tract infections (LRTI). METHODS: Multiplex real-time reverse-transcriptase polymerase chain reaction was undertaken on archived nasopharyngeal aspirates from HIV-infected and –uninfected children (<2 years age) hospitalized for LRTI, who had been previously investigated for respiratory syncytial virus, human metapneumovirus, parainfluenza I–III, adenovirus and influenza A/B. RESULTS: At least one of these viruses were identified in 274 (53.0%) of 517 and in 509 (54.0%) of 943 LRTI-episodes in HIV-infected and -uninfected children, respectively. Human rhinovirus was the most prevalent in HIV-infected (31.7%) and –uninfected children (32.0%), followed by CoV-OC43 (12.2%) and hBoV (9.5%) in HIV-infected; and by hBoV (13.3%) and WUPyV (11.9%) in HIV-uninfected children. Polyomavirus-KI (8.9% vs. 4.8%; p = 0.002) and CoV-OC43 (12.2% vs. 3.6%; p<0.001) were more prevalent in HIV-infected than –uninfected children. Combined with previously-tested viruses, respiratory viruses were identified in 60.9% of HIV-infected and 78.3% of HIV-uninfected children. The newly tested viruses were detected at high frequency in association with other respiratory viruses, including previously-investigated viruses (22.8% in HIV-infected and 28.5% in HIV–uninfected children). CONCLUSIONS: We established that combined with previously-investigated viruses, at least one respiratory virus was identified in the majority of HIV-infected and HIV-uninfected children hospitalized for LRTI. The high frequency of viral co-infections illustrates the complexities in attributing causality to specific viruses in the aetiology of LRTI and may indicate a synergetic role of viral co-infections in the pathogenesis of childhood LRTI.
has issue date	2014-02-03(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0086448
bibo:pmid	24498274
has license	cc-by
sha1sum (hex)	a5243628f77d40d5861c26212a3cc3102d9b2449
schema:url	https://doi.org/10.1371/journal.pone.0086448
resource representing a document's title	Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children
has PubMed Central identifier	PMC3911925
has PubMed identifier	24498274
schema:publication	PLoS One
resource representing a document's body	covid:a5243628f77d40d5861c26212a3cc3102d9b2449#body_text
is schema:about of	named entity 'POLYOMAVIRUSES' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'BACKGROUND' named entity 'RESPIRATORY VIRUSES' named entity 'HUMAN RHINOVIRUS' named entity 'CHILDREN HOSPITALIZED' named entity 'DETERMINE' named entity 'OC43' named entity 'CORONAVIRUSES' named entity 'PNEUMONIA' named entity '229E' named entity 'PATHOGENESIS' named entity 'HAVE' named entity 'NEWLY' named entity 'PREVALENCE' named entity 'HUMAN BOCAVIRUS' named entity 'CLINICAL CHARACTERISTICS' covid:arg/a5243628f77d40d5861c26212a3cc3102d9b2449 named entity 'RHINOVIRUS' named entity 'CHILDREN' named entity 'CLINICAL EPIDEMIOLOGY' named entity 'BOCAVIRUS' named entity 'INFECTED' named entity 'CORONAVIRUSES' named entity 'HIV' named entity 'MOLECULAR DIAGNOSTICS' named entity 'SOUTH AFRICAN' named entity 'UNINFECTED' named entity 'NL63' named entity 'POLYOMAVIRUS' named entity 'HUMAN' named entity 'OC43' named entity '229E' named entity 'CoV' named entity 'viruses' named entity 'human bocavirus' named entity 'Clinical Epidemiology' named entity 'Bocavirus' named entity 'central cyanosis' named entity 'viruses' named entity 'nested PCR' named entity 'hRV' named entity 'HIV' named entity 'adjusted odds ratio' named entity 'virus' named entity 'URTI' named entity 'HIV' named entity 'culture methods' named entity 'viral DNA' named entity 'viruses' named entity 'WHO' named entity 'HIV' named entity 'Streptococcus pneumoniae' named entity 'CRP' named entity 'hRV' named entity 'ARI' named entity 'viruses' named entity 'WUPyV' named entity 'HIV' named entity 'LRTI' named entity 'pathogens' named entity 'hRV' named entity 'p-value' named entity 'bacteria' named entity 'immunofluorescence assay' named entity 'viruses' named entity 'hRV' named entity 'signs and symptoms' named entity 'HIV' named entity 'parainfluenza' named entity 'viruses'

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