About: Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification

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About: Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification
Creator	Cao, Zhigang Cheng, Shipeng Cheng, Yuening Lin, Peng Sun, Yaru Tong, Mingwei Wang, Jianke Yi, Li Deng, Jinliang Li, Jiawei Ren, Jingqiang Zhao, Hang
topic	covid:a51659a324f74a7cf16acd3b1180d203cab2b8d4#this
Source	PMC
abstract	Canine parvovirus (CPV) reproduces by co-opting the resources of host cells, inevitably causing cytotoxic effects to the host cells. Feline kidney F81 cells are sensitive to CPV infection and show disparate growing statuses at different time points post-infection. This study analysed the response of F81 cells to CPV infection at successive infection time points by iTRAQ-based quantitative proteomics. Differentially expressed proteins (DEPs) during 60 h of infection and at selected time points post-infection were identified by an analysis of variance test and a two-tailed unpaired t test, respectively. DEPs with similar quantitative changes were clustered by hierarchical clustering and analysed by gene ontology enrichment, revealing that 12 h and 60 h post-infection were the optimal times to analyse the autonomous parvovirus replication and apoptosis processes, respectively. Using the Metacore(TM) database, 29 DEPs were enriched in a network involved in p53 regulation. Besides, a significantly enriched pathway suggests that the CPV-induced cytopathic effect was probably due to the deficiency of functional CFTR caused by CPV infection. This study uncovered the systemic changes in key cellular factors involved in CPV infection and help to understand the molecular mechanisms of the anti-cancer activity of CPV and the cytopathic effects induced by CPV infection.
has issue date	2016-07-13(xsd:dateTime)
bibo:doi	10.1038/srep29560
bibo:pmid	27406444
has license	cc-by
sha1sum (hex)	a51659a324f74a7cf16acd3b1180d203cab2b8d4
schema:url	https://doi.org/10.1038/srep29560
resource representing a document's title	Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification
has PubMed Central identifier	PMC4942776
has PubMed identifier	27406444
schema:publication	Sci Rep
resource representing a document's body	covid:a51659a324f74a7cf16acd3b1180d203cab2b8d4#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/a51659a324f74a7cf16acd3b1180d203cab2b8d4
is schema:about of	named entity 'clustered' named entity 'key' named entity 'cytopathic' named entity 'induced' named entity 'Proteomic' named entity 'Profiling' named entity 'Response' named entity 'Kinetic' named entity 'KINETIC' named entity 'BASED' named entity 'PROTEOMIC' named entity 'GENE ONTOLOGY' named entity 'DEPS' named entity 'CYTOPATHIC EFFECT' named entity 'REVEALING' named entity 'KEY' named entity 'CANCER' named entity 'ACTIVITY' named entity 'UNDERSTAND' named entity 'NETWORK' named entity 'CHANGES' named entity 'INVOLVED' named entity 'DUE TO' named entity 'ENRICHMENT' named entity 'MOLECULAR' named entity 'APOPTOSIS' named entity 'HELP' named entity 'TIMES' named entity 'MECHANISMS' named entity 'SYSTEMIC' named entity 'HIERARCHICAL CLUSTERING' named entity 'DATABASE' named entity 'FUNCTIONAL' named entity 'STUDY' named entity 'SIMILAR' named entity 'CELLULAR' named entity 'UNCOVERED' named entity 'CELL RESPONSE' named entity 'PATHWAY' named entity 'DEFICIENCY OF' named entity 'CHANGE' named entity 'OPEN' named entity 'SUCCESSIVE' named entity 'IDENTIFICATION' named entity 'RESPONSE TO' named entity 'CPV' named entity 'CFTR' named entity 'POST' named entity 'P53' named entity 'CAUSED BY' named entity 'OPTIMAL' named entity 'USING' named entity 'REGULATION' named entity 'CLUSTERED' named entity 'AUTONOMOUS' named entity 'REPLICATION' named entity 'PARVOVIRUS' named entity 'HOST CELL' named entity 'QUANTITATIVE' named entity 'PROBABLY' named entity 'PROCESSES' named entity 'CANINE PARVOVIRUS INFECTION' named entity 'INDUCED' named entity 'ENRICHED' named entity 'INFECTION' covid:arg/a51659a324f74a7cf16acd3b1180d203cab2b8d4 named entity 'database' named entity 'This'

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