About: Quantifying Type-Specific Reproduction Numbers for Nosocomial Pathogens: Evidence for Heightened Transmission of an Asian Sequence Type 239 MRSA Clone

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About: Quantifying Type-Specific Reproduction Numbers for Nosocomial Pathogens: Evidence for Heightened Transmission of an Asian Sequence Type 239 MRSA Clone Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantifying Type-Specific Reproduction Numbers for Nosocomial Pathogens: Evidence for Heightened Transmission of an Asian Sequence Type 239 MRSA Clone
Creator	Batra, R Cooper, B Kypraios, T Tosas, O Wyncoll, D
Source	PMC
abstract	An important determinant of a pathogen's success is the rate at which it is transmitted from infected to susceptible hosts. Although there are anecdotal reports that methicillin-resistant Staphylococcus aureus (MRSA) clones vary in their transmissibility in hospital settings, attempts to quantify such variation are lacking for common subtypes, as are methods for addressing this question using routinely-collected MRSA screening data in endemic settings. Here we present a method to quantify the time-varying transmissibility of different subtypes of common bacterial nosocomial pathogens using routine surveillance data. The method adapts approaches for estimating reproduction numbers based on the probabilistic reconstruction of epidemic trees, but uses relative hazards rather than serial intervals to assign probabilities to different sources for observed transmission events. The method is applied to data collected as part of a retrospective observational study of a concurrent MRSA outbreak in the United Kingdom with dominant endemic MRSA clones (ST22 and ST36) and an Asian ST239 MRSA strain (ST239-TW) in two linked adult intensive care units, and compared with an approach based on a fully parametric transmission model. The results provide support for the hypothesis that the clones responded differently to an infection control measure based on the use of topical antiseptics, which was more effective at reducing transmission of endemic clones. They also suggest that in one of the two ICUs patients colonized or infected with the ST239-TW MRSA clone had consistently higher risks of transmitting MRSA to patients free of MRSA. These findings represent some of the first quantitative evidence of enhanced transmissibility of a pandemic MRSA lineage, and highlight the potential value of tailoring hospital infection control measures to specific pathogen subtypes.
has issue date	2012-04-12(xsd:dateTime)
bibo:doi	10.1371/journal.pcbi.1002454
bibo:pmid	22511854
has license	cc-by
sha1sum (hex)	a50f2af4833bd314b5664e5f30a6d39792a73f5c
schema:url	https://doi.org/10.1371/journal.pcbi.1002454
resource representing a document's title	Quantifying Type-Specific Reproduction Numbers for Nosocomial Pathogens: Evidence for Heightened Transmission of an Asian Sequence Type 239 MRSA Clone
has PubMed Central identifier	PMC3325179
has PubMed identifier	22511854
schema:publication	PLoS Comput Biol
resource representing a document's body	covid:a50f2af4833bd314b5664e5f30a6d39792a73f5c#body_text
is schema:about of	named entity 'transmissibility' named entity 'higher' named entity 'highlight' named entity 'data' named entity 'infected' named entity 'tailoring' named entity 'transmitted' named entity 'Although' named entity 'compared' named entity 'clones' named entity 'enhanced' named entity 'pandemic' named entity 'CLONE' named entity '239' named entity 'TRANSMISSION' named entity 'EPIDEMIC' named entity 'BUT' named entity 'THEIR' named entity 'DATA' named entity 'PATIENTS' named entity 'FULLY' named entity 'INFECTED' named entity 'DATA COLLECTED' named entity 'MRSA' named entity 'CLONE' named entity 'TOPICAL' named entity 'SETTINGS' named entity 'SURVEILLANCE' named entity 'MEASURE' named entity 'VALUE' named entity 'RATE' named entity 'OBSERVED' named entity 'HIGHER' named entity 'ESTIMATING' named entity 'ENHANCED' named entity 'QUANTITATIVE' named entity 'SUBTYPES' named entity 'BASED' named entity 'REDUCING' named entity 'COMMON' named entity 'ADDRESSING' named entity 'ROUTINE' named entity 'SUCCESS' named entity 'RELATIVE' named entity 'SERIAL' named entity 'TAILORING' named entity 'EFFECTIVE' named entity 'METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS' named entity 'USING' named entity 'INFECTION CONTROL' named entity 'EVENTS' named entity 'SPECIFIC' named entity 'EVIDENCE OF' named entity 'REPRESENT' named entity 'HAZARDS' named entity 'IN HOSPITAL' named entity 'DOMINANT' named entity 'TRANSMITTING' named entity 'SOURCES' named entity 'HOSTS' named entity 'LINEAGE' named entity 'RETROSPECTIVE' named entity 'TRANSMITTED' named entity 'OUTBREAK' named entity 'IMPORTANT' named entity 'USE OF' named entity 'STRAIN' named entity 'SUSCEPTIBLE' named entity 'REPORTS' named entity 'HEIGHTENED' named entity 'PATHOGEN' named entity 'ASIAN' named entity 'VARYING' named entity 'APPROACHES' named entity 'SUGGEST' named entity 'HOSPITAL INFECTION' named entity 'DIFFERENT'

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