About: Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?
Creator	Shao, Anwen Tu, Sheng Wang, Xiaochen Chen, Yiding Kang, Xiaodiao Lenahan, Cameron Lin, Danfeng Shen, Lu
Source	Elsevier; Medline; PMC
abstract	Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis. Accordingly, impaired efferocytosis due to the defective clearance and disrupted stages can lead to a growing number of inflammation- and immune-related diseases. Although numerous studies have shown the mechanisms of efferocytosis, its role in disorders, such as non-tumor and tumor diseases, remains poorly understood. This review summarizes the processes and signal molecules in efferocytosis, and efferocytosis-related functions in non-tumor (e.g., atherosclerosis, lung diseases) and tumor diseases (e.g., breast cancer, prostate cancer), as well as describes the role of involved cytokines. Of note, there is a dual role of efferocytosis in the abovementioned disorders, and a paradoxical effect among non-tumor and tumor diseases in terms of inflammation resolution, immune response, and disease progression. Briefly, intact efferocytosis and cytokines promote tissue repair, while they contribute to tumor progression via the tumor microenvironment and macrophage politzerization. Additionally, this review provides potential targets associated with TAM (TYRO3, AXL, MERTK) receptors and cytokines, such as tumor necrosis factor α and CXCL5, suggesting potential novel therapeutic ways in treating diseases.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1016/j.omto.2020.04.010
bibo:pmid	32346605
has license	no-cc
sha1sum (hex)	a4eece66ddfa81cdcf0c8de475adf780a8e880ea
schema:url	https://doi.org/10.1016/j.omto.2020.04.010
resource representing a document's title	Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?
has PubMed Central identifier	PMC7186127
has PubMed identifier	32346605
schema:publication	Mol Ther Oncolytics
resource representing a document's body	covid:a4eece66ddfa81cdcf0c8de475adf780a8e880ea#body_text
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