About: Experimental Infection of Young Pigs with an Early European Strain of Porcine Epidemic Diarrhoea Virus and a Recent US Strain

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About: Experimental Infection of Young Pigs with an Early European Strain of Porcine Epidemic Diarrhoea Virus and a Recent US Strain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental Infection of Young Pigs with an Early European Strain of Porcine Epidemic Diarrhoea Virus and a Recent US Strain
Creator	Bøtner, A Belsham, G Kjaer, J Krog, J Lohse, L Rasmussen, T Strandbygaard, B
Source	Medline; PMC
abstract	Outbreaks of porcine epidemic diarrhoea (PED) were reported across Europe during the 1980s and 1990s, but only sporadic outbreaks occurred in recent years. PED virus (PEDV) spread for the first time into the USA in 2013 and has caused severe economic losses. Retrospectively, it was found that two different strains of PEDV have been introduced into the United States, both are closely related to strains circulating in China where a new wave of the disease occurred from 2010 onwards. Since autumn 2014, new outbreaks of PED have occurred in Europe. In this study, weaned piglets were inoculated with an early European isolate (Br1/87) or faecal/intestinal suspensions derived from pigs infected with a recent European strain of PEDV (from Germany) or a US strain of PEDV. No evidence for infection resulted from inoculation of pigs with the German sample that contained high levels of PEDV RNA; there were no clinical signs, excretion of viral RNA or anti‐PEDV antibody production. In contrast, all the pigs in the other two groups showed evidence of infection. Mild clinical signs of disease, mainly diarrhoea, occurred in piglets inoculated with the Br1/87 and US PEDV strains. PEDV RNA was detected throughout the intestine in euthanized animals at 4 days post‐inoculation. In addition, within these animals, low levels of viral RNA were detected in lungs and livers with higher levels in spleens. Seroconversion against PEDV occurred in all surviving infected animals within 10 days. PEDV RNA excretion occurred for at least 2 weeks. The US PEDV RNA was detected at low levels in serum samples on multiple days. It is apparent that current diagnostic systems can detect infection by the different virus strains.
has issue date	2016-05-10(xsd:dateTime)
bibo:doi	10.1111/tbed.12509
bibo:pmid	27161288
has license	no-cc
sha1sum (hex)	a4d1457ce611b00d59e4f33ba40da787aefbb04f
schema:url	https://doi.org/10.1111/tbed.12509
resource representing a document's title	Experimental Infection of Young Pigs with an Early European Strain of Porcine Epidemic Diarrhoea Virus and a Recent US Strain
has PubMed Central identifier	PMC7169680
has PubMed identifier	27161288
schema:publication	Transbound Emerg Dis
resource representing a document's body	covid:a4d1457ce611b00d59e4f33ba40da787aefbb04f#body_text
is schema:about of	named entity 'detected' named entity 'detected' named entity 'USA' named entity 'lungs' named entity 'animals' named entity 'infection' named entity 'EPIDEMIC DIARRHOEA' named entity 'DAYS' named entity 'PIGS' named entity 'CIRCULATING' named entity 'PED' named entity 'derived' named entity 'excretion' named entity 'levels' named entity 'United States' named entity 'infected' named entity 'caused' named entity 'viral' named entity 'Mild' named entity 'RNA' named entity 'excretion' named entity 'RNA' named entity 'clinical signs' named entity 'pigs' named entity 'inoculated' named entity 'animals' named entity 'detected' named entity 'diarrhoea' named entity 'Virus' named entity 'virus' named entity 'Seroconversion' named entity 'porcine epidemic diarrhoea' named entity 'Europe' named entity 'signs of disease' named entity 'high levels' named entity 'China' named entity 'antibody' named entity 'spleens' named entity 'Virus' named entity 'German' named entity 'evidence' named entity 'antibodies' named entity 'viral RNA' named entity 'antibodies' named entity 'RNA' named entity 'faeces' named entity 'viral RNA' named entity 'EFSA' named entity 'animal experiments' named entity 'cell culture' named entity 'antigens' named entity 'w/v' named entity 'vomiting' named entity 'virus' named entity 'Europe' named entity 'homogenates' named entity 'RT-qPCR' named entity 'spleen' named entity 'Nucleic Acid' named entity 'EFSA' named entity 'intestine' named entity 'dehydration' named entity 'APHIS' named entity 'antigens' named entity 'United States' named entity 'virus' named entity 'homogenate' named entity 'genus' named entity 'infection' named entity 'viruses' named entity 'cell culture' named entity 'Germany' named entity 'ileum' named entity 'serum' named entity 'RNA'

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